Convergent Evolution of Pathogen Effectors toward Reactive Oxygen Species Signaling Networks in Plants.
Convergent Evolution of Pathogen Effectors toward Reactive Oxygen Species Signaling Networks in Plants.
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DOI：
10.3389/fpls.2017.01687
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发表时间：
2017
影响因子：
5.6
通讯作者：
Hwang BK
中科院分区：
文献类型：
--
作者：
Jwa NS;Hwang BK
微生物病原体已经进化出蛋白质效应物来促进宿主植物的毒力并引起疾病。病原效应物被传递到植物细胞中，抑制植物免疫反应，调节宿主代谢，支持病原体的感染过程。活性氧（Reactive oxygen species， ROS）是触发植物免疫应答的细胞信号分子，如病原体相关分子模式（pathogen-associated molecular pattern， PAMP）触发免疫（PTI）和效应物触发免疫（effector-triggered immunity）。在这篇综述中，我们讨论了针对植物ROS信号通路中多个步骤的病原体效应物的分子功能的最新见解。模式识别受体对PAMPs的感知通过激活NADPH氧化酶、呼吸爆发氧化酶同源物（RBOHs）和过氧化物酶，导致ROS的快速和强烈产生。特定的病原体效应物直接或间接地与植物核苷酸结合的富含亮氨酸的重复受体相互作用，诱导植物细胞产生ROS和过敏反应。相比之下，毒力强的病原体在感染过程中具有能够以不同方式抑制植物ROS爆发的效应物。pamp触发的ROS爆发被靶向丝裂原激活的蛋白激酶级联的病原体效应物抑制。此外，病原体效应物靶向囊泡运输或代谢启动，从而抑制ROS的产生。分泌的病原体效应物阻断代谢辅酶nadp -苹果酸酶，抑制电子向负责ROS生成的NADPH氧化酶（RBOHs）的转移。总的来说，病原体效应物可能已经进化到聚集在一个共同的宿主蛋白网络上，以抑制共同的植物免疫系统，包括植物中的ROS爆发和细胞死亡反应。
Microbial pathogens have evolved protein effectors to promote virulence and cause disease in host plants. Pathogen effectors delivered into plant cells suppress plant immune responses and modulate host metabolism to support the infection processes of pathogens. Reactive oxygen species (ROS) act as cellular signaling molecules to trigger plant immune responses, such as pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity. In this review, we discuss recent insights into the molecular functions of pathogen effectors that target multiple steps in the ROS signaling pathway in plants. The perception of PAMPs by pattern recognition receptors leads to the rapid and strong production of ROS through activation of NADPH oxidase Respiratory Burst Oxidase Homologs (RBOHs) as well as peroxidases. Specific pathogen effectors directly or indirectly interact with plant nucleotide-binding leucine-rich repeat receptors to induce ROS production and the hypersensitive response in plant cells. By contrast, virulent pathogens possess effectors capable of suppressing plant ROS bursts in different ways during infection. PAMP-triggered ROS bursts are suppressed by pathogen effectors that target mitogen-activated protein kinase cascades. Moreover, pathogen effectors target vesicle trafficking or metabolic priming, leading to the suppression of ROS production. Secreted pathogen effectors block the metabolic coenzyme NADP-malic enzyme, inhibiting the transfer of electrons to the NADPH oxidases (RBOHs) responsible for ROS generation. Collectively, pathogen effectors may have evolved to converge on a common host protein network to suppress the common plant immune system, including the ROS burst and cell death response in plants.
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DOI：
10.1126/science.1236011
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dangl JL;Horvath DM;Staskawicz BJ
通讯作者：
Staskawicz BJ
影响因子：
3.4
作者：
An, QL;Hückelhoven, R;Van Bel, AJE
通讯作者：
Van Bel, AJE
影响因子：
64.8
作者：
Chinchilla, Delphine;Zipfel, Cyril;Boller, Thomas
通讯作者：
Boller, Thomas
影响因子：
7.4
作者：
APOSTOL, I;HEINSTEIN, PF;LOW, PS
通讯作者：
LOW, PS
影响因子：
7.4
作者：
Ashtamker, Cher;Kiss, Vladimir;Fluhr, Robert
通讯作者：
Fluhr, Robert