Extinction learning of rewards in the rat: is there a role for CB1 receptors?
Extinction learning of rewards in the rat: is there a role for CB1 receptors?
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DOI：
10.1007/s00213-011-2275-7
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发表时间：
2011-09
影响因子：
3.4
通讯作者：
Cheer, Joseph F.
中科院分区：
文献类型：
--
作者：
Hernandez, Giovanni;Cheer, Joseph F.
内源性大麻素由于其在恢复中的作用而在成瘾和奖励的背景下被广泛研究。然而，很少有人知道CB 1受体的作用，在灭绝学习的食欲动机的任务。本研究的目的是评估内源性大麻素在消退学习不同阶段的作用。通过静脉注射CB 1受体拮抗剂利莫那班（0、200、300 μg/ kg）破坏内源性大麻素信号传导。在学习的获得或巩固阶段。分析了灭绝率及其半衰期，以及在奖励诱导的恢复试验中的觅食行为。我们进一步研究了灭绝和内源性大麻素之间的相互作用，在接受药物治疗，但没有经历灭绝训练（禁欲）的大鼠的不同群体。此外，在线索诱导的恢复试验中研究了利莫那班对线索提取的影响，其中利莫那班（0，300 μg/kg i. v.）是在复职前不久给的在获得或巩固灭绝学习过程中阻断CB 1受体对灭绝率或其半衰期没有影响，这些预处理对奖励寻求行为没有长期影响。此外，接受消退训练的大鼠的反应水平低于在没有消退的情况下接受药物的大鼠（p=0.000，η2=0.40）。利莫那班只有在提示诱导的恢复期前立即给药才能有效抑制行为（p=0.000，η2=0.92）。目前的研究结果澄清和分离的作用，内源性大麻素在恢复的关键介质的线索检索，而不是管弦乐队的灭绝学习过程。
Endocannabinoids have been widely studied in the context of addiction and reward due to their role in reinstatement. However, little is known about the role of CB1 receptors during extinction learning of an appetitively motivated task. The aim of this study was to evaluate the role of endocannabinoids at different stages of extinction learning. Endocannabinoid signaling was disrupted by injecting the CB1 receptor antagonist rimonabant (0, 200, 300 μg/ kg i.v.) during the acquisition or consolidation phases of learning. The rate of extinction and its half-life were analyzed, as well as food-seeking in a reward-induced reinstatement test. We further investigated the interaction between extinction and endocannabinoids in different groups of rats that received drug treatments but did not undergo extinction training (abstinence). In addition, the effects of rimonabant on cue retrieval were investigated in a cue-induced reinstatement test in which rimonabant (0, 300 μg/kg i.v.) was given immediately prior to the reinstatement session. Blockade of CB1 receptors during acquisition or consolidation of extinction learning had no effect on the rate extinction or its half-life and these pretreatments had no long term consequences on reward-seeking behavior. Furthermore, rats that underwent extinction training responded at lower levels than those that received the drug in the absence of extinction (p=0.000, η2=0.40). Rimonabant was effective in inhibiting behavior only if it was immediately given before a cue-induced reinstatement session (p=0.000, η2=0.92). The present results clarify and isolate the role of endocannabinoids in reinstatement as key mediators of cue retrieval, rather than orchestrators of extinction learning processes.
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影响因子：
2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Griebel, G