The role of microRNAs in the regulation of cancer stem cells.
The role of microRNAs in the regulation of cancer stem cells.
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DOI：
10.3389/fgene.2013.00295
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发表时间：
2014-01-03
影响因子：
3.7
通讯作者：
Ochiya T
中科院分区：
文献类型：
--
作者：
Takahashi RU;Miyazaki H;Ochiya T
癌症干细胞（CSCs）已被报道存在于许多人类肿瘤中，并被认为是推动肿瘤发生和发展的关键因素。CSC与正常的体干细胞共享多种生物学特性，例如自我更新的能力、分化后代的繁殖以及特异性细胞表面标志物和干细胞基因的表达。然而，CSC在其化学抗性以及肿瘤发生和转移活性方面不同于正常干细胞。尽管它们具有潜在的临床重要性，但在分子水平上对CSC的调节还没有很好地理解。microRNA（miRNAs）是一类内源性非编码RNA，在细胞、生理和发育过程中发挥重要作用。异常的miRNA表达与包括癌症在内的许多人类疾病相关。miRNA参与CSC特性的调节;因此，更好地理解miRNA对CSC基因表达的调节可以帮助鉴定有前途的生物标志物和治疗靶点。在本综述中，我们总结了miRNA对CSC调控的主要发现，并讨论了最近的进展，这些进展提高了我们对miRNA网络调控CSC的理解，并可能导致特异性靶向CSC的miRNA治疗剂的开发。
Cancer stem cells (CSCs) have been reported in many human tumors and are proposed to drive tumor initiation and progression. CSCs share a variety of biological properties with normal somatic stem cells such as the capacity for self-renewal, the propagation of differentiated progeny, and the expression of specific cell surface markers and stem cell genes. However, CSCs differ from normal stem cells in their chemoresistance and tumorigenic and metastatic activities. Despite their potential clinical importance, the regulation of CSCs at the molecular level is not well-understood. MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs that play an important role in the regulation of several cellular, physiological, and developmental processes. Aberrant miRNA expression is associated with many human diseases including cancer. miRNAs have been implicated in the regulation of CSC properties; therefore, a better understanding of the modulation of CSC gene expression by miRNAs could aid the identification of promising biomarkers and therapeutic targets. In the present review, we summarize the major findings on the regulation of CSCs by miRNAs and discuss recent advances that have improved our understanding of the regulation of CSCs by miRNA networks and may lead to the development of miRNA therapeutics specifically targeting CSCs.
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DOI：
10.1084/jem.20090831
发表时间：
2010-03-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Han YC;Park CY;Bhagat G;Zhang J;Wang Y;Fan JB;Liu M;Zou Y;Weissman IL;Gu H
通讯作者：
Gu H
影响因子：
3.7
作者：
Garzia L;Andolfo I;Cusanelli E;Marino N;Petrosino G;De Martino D;Esposito V;Galeone A;Navas L;Esposito S;Gargiulo S;Fattet S;Donofrio V;Cinalli G;Brunetti A;Vecchio LD;Northcott PA;Delattre O;Taylor MD;Iolascon A;Zollo M
通讯作者：
Zollo M
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
12.4
作者：
Eramo, A.;Lotti, F.;De Maria, R.
通讯作者：
De Maria, R.
DOI：
10.1073/pnas.0703478104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Dalerba, Piero;Dylla, Scott J.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.