microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia.
microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia.
复制标题
DOI：
10.1084/jem.20090831
复制
发表时间：
2010-03-15
期刊：
影响因子：
--
通讯作者：
Gu H
中科院分区：
文献类型：
--
作者：
Han YC;Park CY;Bhagat G;Zhang J;Wang Y;Fan JB;Liu M;Zou Y;Weissman IL;Gu H
MicroRNAs(MiRNAs)在造血干细胞(HSCs)、定向祖细胞和白血病干细胞(LSCs)中的功能还知之甚少。我们发现miR-29a在HSC中高表达，在造血祖细胞中低表达。MiR-29a在小鼠HSC/祖细胞中的异位表达导致髓系祖细胞获得自我更新能力，偏向髓系分化，并发展为骨髓增生性疾病，进展为急性髓系白血病(AML)。MIR-29a通过加速G1向S/G2细胞周期的转变促进祖细胞增殖。MiR-29a在人AML中高表达，与人LSC一样，表达miR-29a的髓系祖细胞可以连续移植AML。我们的数据表明miR-29a调节早期造血，并提示miR-29a通过将髓系祖细胞转化为自我更新的LSC而启动AML。
The function of microRNAs (miRNAs) in hematopoietic stem cells (HSCs), committed progenitors, and leukemia stem cells (LSCs) is poorly understood. We show that miR-29a is highly expressed in HSC and down-regulated in hematopoietic progenitors. Ectopic expression of miR-29a in mouse HSC/progenitors results in acquisition of self-renewal capacity by myeloid progenitors, biased myeloid differentiation, and the development of a myeloproliferative disorder that progresses to acute myeloid leukemia (AML). miR-29a promotes progenitor proliferation by expediting G1 to S/G2 cell cycle transitions. miR-29a is overexpressed in human AML and, like human LSC, miR-29a-expressing myeloid progenitors serially transplant AML. Our data indicate that miR-29a regulates early hematopoiesis and suggest that miR-29a initiates AML by converting myeloid progenitors into self-renewing LSC.
登录
查看更多内容
影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
14.9
作者：
Chen C;Ridzon DA;Broomer AJ;Zhou Z;Lee DH;Nguyen JT;Barbisin M;Xu NL;Mahuvakar VR;Andersen MR;Lao KQ;Livak KJ;Guegler KJ
通讯作者：
Guegler KJ
影响因子：
158.5
作者：
Jamieson, CHM;Ailles, LE;Weissman, IL
通讯作者：
Weissman, IL
影响因子：
3.2
作者：
Garzon, Ramiro;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
64.5
作者：
Lewis, BP;Shih, IH;Burge, CB
通讯作者：
Burge, CB