Inflammasomes as mediators of immunity against influenza virus.
Inflammasomes as mediators of immunity against influenza virus.
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DOI：
10.1016/j.it.2010.11.004
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发表时间：
2011-01
影响因子：
16.8
通讯作者：
Iwasaki A
中科院分区：
文献类型：
--
作者：
Pang IK;Iwasaki A
Influenza viruses infect a wide range of avian and mammalian host species including humans. Infections with influenza viruses are responsible for major causes of human respiratory infections and mortality. Influenza viruses are recognized by the innate immune system through multiple mechanisms. These include endosomal recognition through the Toll-like receptor 7 (TLR7) and cytosolic recognition through the retinoic acid inducible gene I (RIG-I). Recent studies also identified the role of NOD-like receptors (NLR) in innate detection of influenza viruses leading to the activation of the inflammasomes. Here, we review the cellular and molecular mechanisms by which influenza virus infection leads to inflammasome activation, and discuss the consequences of such activation in innate and adaptive immune defense against influenza viruses.
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