Influence of a cigarette smoke extract on the hormonal regulation of platelet-activating factor acetylhydrolase in rats.
Influence of a cigarette smoke extract on the hormonal regulation of platelet-activating factor acetylhydrolase in rats.
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香烟烟雾提取物对大鼠血小板活化因子乙酰水解酶激素调节的影响。
DOI：
10.1095/biolreprod53.2.244
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发表时间：
1995
影响因子：
3.6
通讯作者：
I. Sawaragi
中科院分区：
文献类型：
--
作者：
K. Yasuda;M. Takashima;I. Sawaragi
我们评估了雌激素、孕酮和香烟烟雾提取物（CSE）对大鼠血浆血小板活化因子（PAF）乙酰水解酶（AH; PAF-AH）活性的影响。静脉注射PAF对大鼠组织的影响是我们研究血栓形成机制的一部分。成年雌性大鼠（14周龄）经17 α-乙炔基炔雌醇（100微克/千克，5天）处理后，血浆PAF-AH活性降低70%。甲羟孕酮（50 mg/kg，5天）增加PAF-AH活性的50%。CSE（0.5支/kg，5天）在治疗期间未改变PAF-AH活性。然而，CSE和17 α-乙炔基炔雌醇的组合使血浆PAF-AH活性降低90%。PAF-AH活性的降低具有年龄依赖性。甲孕酮对血浆PAF-AH活性的影响不受CSE的影响。将PAF（5-40 nmol/kg）静脉注射到未处理的成年雌性大鼠中，16只动物中有9只在20 nmol/kg剂量的PAF后死亡。肉眼检查结果包括肺和心脏出血、充血和充血，以及胃肠道坏死样变化。显微镜下，在肺和心脏中观察到血栓。用性类固醇激素预处理的成年雌性大鼠给予PAF后，17 α-乙炔基炔雌醇引起的低血浆PAF-AH活性大鼠的死亡率增加，而甲羟孕酮引起的高血浆PAF-AH活性大鼠的死亡率降低。因此，PAF和PAF-AH可能在已知使用口服避孕药的女性吸烟者发生的血栓形成事件中发挥重要作用。
We evaluated the effects of estrogen, progestin, and cigarette smoke extract (CSE) on plasma platelet-activating factor (PAF) acetylhydrolase (AH; PAF-AH) activity in rats. The effects on rat tissues of an i.v. injection of PAF were studied as part of our investigation of the mechanisms involved in thrombotic episodes. Plasma PAF-AH activity in adult female rats (14 wk of age) treated with 17 alpha-ethynylestradiol (100 micrograms/kg, 5 days) was decreased by 70%. Medroxyprogesterone (50 mg/kg, 5 days) increased PAF-AH activity by 50%. CSE (0.5 cigarette/kg, 5 days) did not alter PAF-AH activity during the treatment. However, a combination of CSE and 17 alpha-ethynylestradiol decreased plasma PAF-AH activity by 90%. The decrease in PAF-AH activity was age-dependent. The effect of medroxyprogesterone on plasma PAF-AH activity was not influenced by CSE. When PAF (5-40 nmol/kg) was injected i.v. into untreated adult female rats, 9 of 16 animals died after a 20-nmol/kg dose of PAF. Macroscopic findings included hemorrhage, hyperemia, and congestion in the lungs and heart, and necrosis-like changes in the gastrointestinal tract. Microscopically, thrombi were observed in the lungs and heart. When PAF was administered to adult female rats pretreated with sex steroid hormones, the mortality of rats with low plasma PAF-AH activity caused by 17 alpha-ethynylestradiol was increased but that of rats with high PAF-AH activity caused by medroxyprogesterone was decreased. Thus, PAF and PAF-AH may play important roles in the thrombotic episodes known to occur in female smokers who use oral contraceptives.
妊娠和哺乳期间母体、胎儿和新生兔血浆中的血小板激活因子乙酰水解酶活性。
DOI：
10.1073/pnas.85.3.728
发表时间：
1988
影响因子：
11.1
作者：
Maki,N;Hoffman,DR;Johnston,JM
通讯作者：
Johnston,JM
1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（一种降血压和血小板活化脂质）的特异性乙酰水解酶。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Blank,ML;Lee,T;Fitzgerald,V;Snyder,F
通讯作者：
Snyder,F
人羊水和尿液中磷脂血小板激活因子（1-0-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）的鉴定。
DOI：
10.1016/0006-291x(83)90430-8
发表时间：
1983
影响因子：
3.1
作者：
Billah,MM;Johnston,JM
通讯作者：
Johnston,JM