Chromatin Structure and Drug Resistance in Candida spp.
Chromatin Structure and Drug Resistance in Candida spp.
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DOI：
10.3390/jof6030121
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发表时间：
2020-07-30
期刊：
影响因子：
--
通讯作者：
M Hyland E
中科院分区：
文献类型：
--
作者：
O'Kane CJ;Weild R;M Hyland E
抗生素耐药性（AMR）是目前对全球人类健康最严重的威胁之一，解决AMR的研究得到了科学界的大量投资和广泛关注。然而，大多数这些努力集中在抗生素上，相比之下，对抗真菌耐药性（AFR）的研究远远不足。鉴于越来越多的脆弱的、免疫功能低下的个体，以及全球变暖对真菌生长的积极影响，迫切需要解决真菌疾病和AFR的令人不安的上升。染色质结构和基因表达调控在真菌物种适应抗真菌胁迫中起着关键作用，在这篇综述中，我们讨论了遗传和表观遗传机制，染色质结构可以决定AFR机制，并将提供致病酵母，特别是念珠菌属，修改染色质结构，以促进抗真菌药物存在下的存活。我们还讨论了抗染色质治疗的机制，特别是赖氨酸脱乙酰酶抑制剂，影响收购和表型表达的AFR念珠菌。以及它们作为减轻AFR的有效佐剂的潜力。
Anti-microbial resistance (AMR) is currently one of the most serious threats to global human health and, appropriately, research to tackle AMR garnishes significant investment and extensive attention from the scientific community. However, most of this effort focuses on antibiotics, and research into anti-fungal resistance (AFR) is vastly under-represented in comparison. Given the growing number of vulnerable, immunocompromised individuals, as well as the positive impact global warming has on fungal growth, there is an immediate urgency to tackle fungal disease, and the disturbing rise in AFR. Chromatin structure and gene expression regulation play pivotal roles in the adaptation of fungal species to anti-fungal stress, suggesting a potential therapeutic avenue to tackle AFR. In this review we discuss both the genetic and epigenetic mechanisms by which chromatin structure can dictate AFR mechanisms and will present evidence of how pathogenic yeast, specifically from the Candida genus, modify chromatin structure to promote survival in the presence of anti-fungal drugs. We also discuss the mechanisms by which anti-chromatin therapy, specifically lysine deacetylase inhibitors, influence the acquisition and phenotypic expression of AFR in Candida spp. and their potential as effective adjuvants to mitigate against AFR.
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影响因子：
5.2
作者：
Chaillot J;Tebbji F;García C;Wurtele H;Pelletier R;Sellam A
通讯作者：
Sellam A
DOI：
10.1073/pnas.0912427107
发表时间：
2010-01-26
影响因子：
11.1
作者：
da Rosa, Jessica Lopes;Boyartchuk, Victor L.;Kaufman, Paul D.
通讯作者：
Kaufman, Paul D.
DOI：
10.1126/science.aad3292
发表时间：
2016-01-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Kishony R
影响因子：
6.4
作者：
Arendrup, Maiken Cavling;Patterson, Thomas F.
通讯作者：
Patterson, Thomas F.
影响因子：
7.1
作者：
Cortegiani A;Misseri G;Fasciana T;Giammanco A;Giarratano A;Chowdhary A
通讯作者：
Chowdhary A