Bacteroides plebeius improves muscle wasting in chronic kidney disease by modulating the gut-renal muscle axis.
Bacteroides plebeius improves muscle wasting in chronic kidney disease by modulating the gut-renal muscle axis.
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拟杆菌通过调节肠-肾肌轴改善慢性肾脏疾病的肌肉萎缩。
DOI：
10.1111/jcmm.17626
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发表时间：
2022-12
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性肾病 (CKD) 影响着全球约 10% 的人口。几乎所有类型的 CKD 患者都会出现肌肉萎缩，而肠道微生物组与慢性肾衰竭 (CRF) 期间的蛋白质消耗密切相关。本研究调查了 Bacteroides plebeius 对 CKD 大鼠蛋白质能量消耗的影响，我们的结果表明 Bacteroides plebeius 可能通过 Mystn/ActRIIB/SMAD2 途径对抗肌肉萎缩。总共5/6 Nx大鼠被用作CKD肌肉萎缩模型。对肌肉萎缩的大鼠给予拟杆菌(Bacteroides plebeius)(2××108cfu/0.2ml)，持续8周。结果表明，使用 Bacteroides plebeius 可显着抑制 CKD 患者的肌肉萎缩。高通量 16S rRNA 焦磷酸测序显示，补充 Bacteroides plebeius 可挽救肠道微生物群的紊乱。普通拟杆菌还可以增强肠粘膜的屏障功能。普通拟杆菌可以通过增加益生菌的丰度和减少对肠粘膜屏障的损害来调节肠道微生物组并减少蛋白质消耗。我们的研究结果表明，Bacteroides plebeius 可能通过 Mystn/ActRIIB/SMAD2 途径对抗肌肉萎缩。
Chronic kidney disease (CKD) affects approximately 10% of the global population. Muscle atrophy occurs in patients with almost all types of CKD, and the gut microbiome is closely related to protein consumption during chronic renal failure (CRF). This study investigated the effects of Bacteroides plebeius on protein energy consumption in rats with CKD, and our results suggest that Bacteroides plebeius may combat muscle atrophy through the Mystn/ActRIIB/SMAD2 pathway. A total of 5/6 Nx rats were used as a model of muscle wasting in CKD. The rats with muscle wasting were administered Bacteroides plebeius (2 × 108 cfu/0.2 ml) for 8 weeks. The results showed that Bacteroides plebeius administration significantly inhibited muscle wasting in CKD. High‐throughput 16 S rRNA pyrosequencing revealed that supplementation with Bacteroides plebeius rescued disturbances in the gut microbiota. Bacteroides plebeius could also enhance the barrier function of the intestinal mucosa. Bacteroides plebeius may modulate the gut microbiome and reduce protein consumption by increasing the abundance of probiotics and reducing damage to the intestinal mucosal barrier. Our findings suggest that Bacteroides plebeius may combat muscle atrophy through the Mystn/ActRIIB/SMAD2 pathway.
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影响因子：
13.6
作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.1219451110
发表时间：
2013-05-28
影响因子：
11.1
作者：
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通讯作者：
Cani, Patrice D.
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