miRecords: an integrated resource for microRNA-target interactions.

miRecords: an integrated resource for microRNA-target interactions.
复制标题

DOI:
10.1093/nar/gkn851
复制
发表时间:
2009-01
影响因子:
14.9
通讯作者:
Li T
Li T
中科院分区:
生物学2区
文献类型:
--
作者:
Xiao F;Zuo Z;Cai G;Kang S;Gao X;Li T

文献摘要

参考文献

被引文献

相似文献

microRNAs(miRNAs)是一类重要的非编码小分子RNA,能够调控其他基因的表达。近年来,miRNAs的计算靶点预测研究取得了很大进展。目前已经建立了10多个miRNA靶点预测程序,但动物miRNA靶点的预测仍然是一项具有挑战性的任务。我们已经开发了miRecords,这是一种用于动物miRNA-靶标相互作用的综合资源。该资源的Validated Targets组件托管了一个大型的,高质量的手动管理的实验验证的miRNA-靶标相互作用数据库,并为每个相互作用提供了实验支持的系统文档。该数据库的当前版本包括7个动物物种中301个miRNA和902个靶基因之间的1135个经验证的miRNA-靶相互作用记录。miRecords的Predicted Targets组件存储了由11个已建立的miRNA靶标预测程序产生的预测miRNA靶标。miRecords不仅可以为实验性miRNA研究人员提供有用的资源,还可以为开发下一代miRNA靶点预测程序的信息学科学家提供有用的资源。miRecords可在http://miRecords.umn.edu/miRecords上获得。
MicroRNAs (miRNAs) are an important class of small noncoding RNAs capable of regulating other genes’ expression. Much progress has been made in computational target prediction of miRNAs in recent years. More than 10 miRNA target prediction programs have been established, yet, the prediction of animal miRNA targets remains a challenging task. We have developed miRecords, an integrated resource for animal miRNA–target interactions. The Validated Targets component of this resource hosts a large, high-quality manually curated database of experimentally validated miRNA–target interactions with systematic documentation of experimental support for each interaction. The current release of this database includes 1135 records of validated miRNA–target interactions between 301 miRNAs and 902 target genes in seven animal species. The Predicted Targets component of miRecords stores predicted miRNA targets produced by 11 established miRNA target prediction programs. miRecords is expected to serve as a useful resource not only for experimental miRNA researchers, but also for informatics scientists developing the next-generation miRNA target prediction programs. The miRecords is available at http://miRecords.umn.edu/miRecords.
DOI: 10.1186/1471-2105-7-411
发表时间: 2006-09-18
期刊: BMC bioinformatics
影响因子: 3
作者:
Kim SK;Nam JW;Rhee JK;Lee WJ;Zhang BT
通讯作者: Zhang BT
DOI: 10.1128/mcb.00242-06
发表时间: 2006-11-01
影响因子: 5.3
作者:
Hossain, Anwar;Kuo, Macus T.;Saunders, Grady F.
通讯作者: Saunders, Grady F.
DOI: 10.1016/j.devcel.2004.12.019
发表时间: 2005-03-01
期刊: DEVELOPMENTAL CELL
影响因子: 11.8
作者:
Grosshans, H;Johnson, T;Slack, FJ
通讯作者: Slack, FJ
DOI: 10.1016/s0092-8674(03)01018-3
发表时间: 2003-12-26
期刊: CELL
影响因子: 64.5
作者:
Lewis, BP;Shih, IH;Burge, CB
通讯作者: Burge, CB
Mirbase:MicroRNA基因组学的工具。
DOI: 10.1093/nar/gkm952
发表时间: 2008-01
影响因子: 14.9
作者:
Griffiths-Jones, Sam;Saini, Harpreet Kaur;van Dongen, Stijn;Enright, Anton J.
通讯作者: Enright, Anton J.