Altered cerebral blood flow in patients with spinocerebellar degeneration.
Altered cerebral blood flow in patients with spinocerebellar degeneration.
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DOI：
10.3389/fnins.2022.977145
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发表时间：
2022
影响因子：
4.3
通讯作者：
Ma, Guolin
中科院分区：
文献类型：
--
作者：
Liu, Bing;Yang, Aocai;Gao, Wenwen;Chen, Yue;Wang, Yige;Liu, Xiuxiu;Lv, Kuan;Zhang, Linwei;Ma, Guolin
关键词：
脊髓小脑变性（SCD）包括具有散发性和遗传性形式的多种病症，包括脊髓小脑共济失调（SCA）。除了进行性小脑共济失调和结构性萎缩外，还观察到SCD的血流动力学改变。本研究旨在通过动脉自旋标记（arterial spin labeling，ASL）技术探讨SCD患者全脑脑血流改变模式及其与疾病严重程度和心理异常的关系。前瞻性招募30例SCD患者和30例年龄和性别匹配的健康对照（HC），并在3.0T MR扫描仪上进行ASL检查。采用共济失调评定量表（SARA）和国际共济失调评定量表（ICARS）评分评估SCD患者的疾病严重程度。采用焦虑自评量表（SAS）、抑郁自评量表（SDS）和睡眠自评量表（SRSS）评定患者的焦虑、抑郁和睡眠状况。我们在体素水平上比较了SCD组和HC组的全脑CBF值。对SCD组患者进行脑血流与疾病严重程度、心理异常的相关分析。与HC相比，SCD患者表现出两个簇的CBF值降低（FWE校正P <0.05），包括小脑簇1的双侧齿状核和顶核，双侧小脑小叶I-IV，V和IX，左小叶VI，右小叶VIIIb，小脑蚓部小叶IX和X，以及中脑簇2的中缝核背侧部。小脑簇1脑血流量与SARA评分（斯皮尔曼rho =-0.374，P = 0.042）和SDS标准评分（斯皮尔曼rho =-0.388，P = 0.034）呈负相关。中脑2区CBF与SARA评分（斯皮尔曼rho =-0.370，P = 0.044）和ICARS评分（Pearson r =-0.464，P = 0.010）呈负相关。SCD相关的全脑CBF改变主要累及小脑和脑干中脑，与手、足、舌运动相关功能小脑区部分重叠。脑血流量下降与SCD的病情严重程度和抑郁状态有关。因此，脑血流量可能是一个很有前途的神经影像学生物标志物，以反映SCD的严重程度和提示精神的变化。
Spinocerebellar degeneration (SCD) comprises a multitude of disorders with sporadic and hereditary forms, including spinocerebellar ataxia (SCA). Except for progressive cerebellar ataxia and structural atrophy, hemodynamic changes have also been observed in SCD. This study aimed to explore the whole-brain patterns of altered cerebral blood flow (CBF) and its correlations with disease severity and psychological abnormalities in SCD via arterial spin labeling (ASL). Thirty SCD patients and 30 age- and sex-matched healthy controls (HC) were prospectively recruited and underwent ASL examination on a 3.0T MR scanner. The Scale for Assessment and Rating of Ataxia (SARA) and the International Cooperative Ataxia Rating Scale (ICARS) scores were used to evaluate the disease severity in SCD patients. Additionally, the status of anxiety, depression and sleep among all patients were, respectively, evaluated by the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) and Self-Rating Scale of Sleep (SRSS). We compared the whole-brain CBF value between SCD group and HC group at the voxel level. Then, the correlation analyses between CBF and disease severity, and psychological abnormalities were performed on SCD group. Compared with HC, SCD patients demonstrated decreased CBF value in two clusters (FWE corrected P < 0.05), covering bilateral dentate and fastigial nuclei, bilateral cerebellar lobules I-IV, V and IX, left lobule VI, right lobule VIIIb, lobules IX and X of the vermis in the cerebellar Cluster 1 and the dorsal part of raphe nucleus in the midbrain Cluster 2. The CBF of cerebellar Cluster 1 was negatively correlated with SARA scores (Spearman’s rho = –0.374, P = 0.042) and SDS standard scores (Spearman’s rho = –0.388, P = 0.034), respectively. And, the CBF of midbrain Cluster 2 also had negative correlations with SARA scores (Spearman’s rho = –0.370, P = 0.044) and ICARS scores (Pearson r = –0.464, P = 0.010). The SCD-related whole-brain CBF changes mainly involved in the cerebellum and the midbrain of brainstem, which are partially overlapped with the related function cerebellar areas of hand, foot and tongue movement. Decreased CBF was related to disease severity and depression status in SCD. Therefore, CBF may be a promising neuroimaging biomarker to reflect the severity of SCD and suggest mental changes.
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影响因子：
4.1
作者：
Erro, Roberto;Ponticorvo, Sara;Pellecchia, Maria Teresa
通讯作者：
Pellecchia, Maria Teresa
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
影响因子：
9.9
作者：
GILMAN, S;STLAURENT, RT;LOHMAN, M
通讯作者：
LOHMAN, M
影响因子：
3.3
作者：
Hellenbroich, Y.;Gierga, K.;Rueb, U.
通讯作者：
Rueb, U.
影响因子：
3.3
作者：
DETRE, JA;LEIGH, JS;KORETSKY, AP
通讯作者：
KORETSKY, AP