Autophagy and viruses: adversaries or allies?

Autophagy and viruses: adversaries or allies?
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DOI:
10.1159/000346388
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发表时间:
2013
影响因子:
5.3
通讯作者:
Levine B
Levine B
中科院分区:
医学2区
文献类型:
--
作者:
Dong X;Levine B

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自噬途径是宿主防御病毒感染、协调病原体降解(异噬)、先天免疫信号传导和适应性免疫的某些方面的重要组成部分。单个自噬蛋白或核心自噬机制的盒也可以独立于经典自噬途径作为抗病毒因子发挥作用。此外,为了在宿主中生存和繁殖,病毒已经进化出各种策略来逃避自噬攻击并操纵自噬机制以获得自身利益。本文综述了近年来在理解自噬的抗病毒和前病毒作用以及自噬相关基因的自噬独立功能方面的进展。
The autophagy pathway is an essential component of host defense against viral infection, orchestrating pathogen degradation (xenophagy), innate immune signaling, and certain aspects of adaptive immunity. Single autophagy proteins or cassettes of the core autophagy machinery can also function as antiviral factors independently of the canonical autophagy pathway. Moreover, to survive and propagate within the host, viruses have evolved a variety of strategies to evade autophagic attack and manipulate the autophagy machinery for their own benefit. This Review summarizes recent advances in understanding the antiviral and proviral roles of autophagy and previously unappreciated autophagy-independent functions of autophagy-related genes.
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