Subthreshold membrane currents confer distinct tuning properties that enable neurons to encode the integral or derivative of their input.
Subthreshold membrane currents confer distinct tuning properties that enable neurons to encode the integral or derivative of their input.
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DOI：
10.3389/fncel.2014.00452
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发表时间：
2014
影响因子：
5.3
通讯作者：
Prescott SA
中科院分区：
文献类型：
--
作者：
Ratté S;Lankarany M;Rho YA;Patterson A;Prescott SA
神经元依靠动作电位或尖峰信号来编码信息。但是尖峰脉冲可以在不同的神经元中编码不同的刺激特征。在这里，我们通过模拟和实验表明，神经元如何编码的积分或导数的输入的基础上赋予他们的阈下电流的不同的调谐性能。慢激活阈下内向（去极化）电流介导阈下电压的正反馈控制，维持去极化并允许神经元根据其整合的刺激波形发放尖峰。慢激活阈下外向（超极化）电流介导阈下电压的负反馈控制，截断去极化并迫使神经元根据其分化的刺激波形发放尖峰。根据其方向，慢激活阈下电流合作或竞争与快速激活内向电流在尖峰启动。这种解释预测，敏感性的变化率的刺激强度不同的定性之间的积分器和微分器。这在脊髓感觉神经元中得到了实验证实，这些神经元自然地表现为专门的积分器或微分器。预测不同的刺激功能的敏感性，证实了协方差分析。积分和微分，这本身是逆操作，因此被证明是由慢反馈介导的相反方向的阈下电流在不同的神经元中表达。
Neurons rely on action potentials, or spikes, to encode information. But spikes can encode different stimulus features in different neurons. We show here through simulations and experiments how neurons encode the integral or derivative of their input based on the distinct tuning properties conferred upon them by subthreshold currents. Slow-activating subthreshold inward (depolarizing) current mediates positive feedback control of subthreshold voltage, sustaining depolarization and allowing the neuron to spike on the basis of its integrated stimulus waveform. Slow-activating subthreshold outward (hyperpolarizing) current mediates negative feedback control of subthreshold voltage, truncating depolarization and forcing the neuron to spike on the basis of its differentiated stimulus waveform. Depending on its direction, slow-activating subthreshold current cooperates or competes with fast-activating inward current during spike initiation. This explanation predicts that sensitivity to the rate of change of stimulus intensity differs qualitatively between integrators and differentiators. This was confirmed experimentally in spinal sensory neurons that naturally behave as specialized integrators or differentiators. Predicted sensitivity to different stimulus features was confirmed by covariance analysis. Integration and differentiation, which are themselves inverse operations, are thus shown to be implemented by the slow feedback mediated by oppositely directed subthreshold currents expressed in different neurons.
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