Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis.
Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis.
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DOI：
10.2174/157015911795017335
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发表时间：
2011-03
影响因子：
5.3
通讯作者：
Sora I
中科院分区：
文献类型：
--
作者：
Kobayashi H;Ujike H;Iwata N;Inada T;Yamada M;Sekine Y;Uchimura N;Iyo M;Ozaki N;Itokawa M;Sora I
越来越多的证据表明，血清素能系统调节多巴胺能神经传递。我们分析了日本人群中脑色氨酸羟化酶 2 (TPH2) 基因（一种血清素生物合成限速酶）变异与甲基苯丙胺 (METH) 依赖/精神病之间的关联。我们在 TPH2 基因外显子和外显子-内含子边界发现了 10 个单核苷酸多态性 (SNP) 和 2 个多核苷酸多态性。总共 162 名患者和 243 名对照者被用于这些多态性与 METH 依赖/精神病之间的关联分析。冰毒依赖/精神病患者与对照组之间的基因型或等位基因频率没有观察到显着差异。基于单倍型频率的样本间差异的全局测试显示没有显着关联。关于精神病潜伏期、精神病预后和自发复发，我们发现这些 SNP 没有显着关联。这些结果表明，TPH2 基因变异可能不是易患冰毒依赖/精神病的因素。
There is a growing evidence that serotoninergic systems modulate dopaminergic neurotransmission. We analyzed the association between the variations in the brain tryptophan hydroxylase 2 (TPH2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (METH) dependence/psychosis in a Japanese population. We found ten single nucleotide polymorphisms (SNPs) and two polynucleotide polymorphisms in TPH2 gene exons and exon-intron boundaries. A total of 162 patients and 243 controls were used for the association analysis between these polymorphisms and METH dependence/psychosis. No significant differences were observed in either genotypic or allelic frequencies between METH dependent/psychotic patients and controls. A global test of differentiation among samples based on haplotype frequencies showed no significant association. With respect to latency of psychosis, prognosis of psychosis, and spontaneous relapse, we found no significant association with these SNPs. These results suggest that the TPH2 gene variants may not be a factor in vulnerability to METH dependence/psychosis.
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影响因子：
2.8
作者：
Ujike, H;Harano, M;Ozaki, N
通讯作者：
Ozaki, N
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通讯作者：
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