Computational Approaches to tRNA-Derived Small RNAs.
Computational Approaches to tRNA-Derived Small RNAs.
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tRNA 衍生小 RNA 的计算方法
DOI:
10.3390/ncrna3010002
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发表时间:
2017-01-04
期刊:
影响因子:
4.3
通讯作者:
Zheng LL
中科院分区:
文献类型:
--
作者:
Xu WL;Yang Y;Wang YD;Qu LH;Zheng LL
tRNA-derived small RNAs (tDRs) are a group of small, non-coding RNAs derived from transfer RNAs (tRNAs). They can be classified as tRNA halves and tRNA-derived small RNA fragments (tRFs). Accumulating experimental evidence suggests their functional roles in cells and in various biological processes. Advances in next-generation sequencing (NGS) techniques allow a large amount of small RNA deep-sequencing data to be generated. To investigate tDRs from these data, software to identify tDRs and databases to retrieve or manage tDR data have been devised. In this review, we summarized the tools and databases for tDR identification and collection, with the aim of helping researchers choose the best tools for their analysis and inspiring the invention or improvement of tools in the field.
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