The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks.
The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks.
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DOI：
10.1162/jocn_a_00366
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发表时间：
2013-07
影响因子：
3.2
通讯作者：
Sperling RA
中科院分区：
文献类型：
--
作者：
Huijbers W;Schultz AP;Vannini P;McLaren DG;Wigman SE;Ward AM;Hedden T;Sperling RA
功能性磁共振成像（fMRI）研究已经将后内侧皮层与情景学习（编码）和记忆（提取）过程联系起来。后内侧皮层被认为是默认网络的一部分，在编码过程中趋于失活，但在提取过程中被激活，这种模式被称为编码/提取翻转。然而，记忆表现（命中/未命中）和记忆阶段（编码/检索）的神经相关性之间的确切关系以及与内在皮层网络的重叠程度仍有待阐明。使用基于任务的功能磁共振成像，我们分离的活动模式与记忆性能，记忆阶段和两者之间的相互作用。利用静息态功能磁共振成像，我们确定了哪些内在的大规模功能网络与显示任务诱导效应的区域重叠。我们的研究结果表明，成功的记忆表现在与控制网络和腹侧注意网络的影响不成功的记忆表现的区域。我们发现，在跨越默认网络和控制网络的大脑区域中，记忆提取的效果。最后，我们发现了与默认网络相关的大脑区域，包括后内侧皮层，后顶叶皮层和海马旁皮层的记忆表现和记忆阶段之间的相互作用。我们讨论这些发现的编码/检索翻转。总的来说，研究结果表明，任务引起的影响跨越内在皮层网络。此外，默认网络中的区域显示功能分离，这可能对年龄相关记忆障碍的神经基础有影响。
Functional MRI (fMRI) studies have linked the posteromedial cortex to episodic learning (encoding) and remembering (retrieval) processes. The posteromedial cortex is considered part of the default network and tends to deactivate during encoding, but activate during retrieval, a pattern known as the encoding/retrieval flip. Yet, the exact relationship between the neural correlates of memory performance (hit/miss) and memory stage (encoding/retrieval) and the extent of overlap with intrinsic cortical networks remains to be elucidated. Using task-based fMRI, we isolated the pattern of activity associated with memory performance, memory stage and the interaction between both. Using resting-state fMRI, we identified which intrinsic large-scale functional networks overlapped with regions showing task-induced effects. Our results demonstrated an effect of successful memory performance in regions associated with the control network and an effect of unsuccessful memory performance in the ventral attention network. We found an effect of memory retrieval in brain regions that span the default and control networks. Finally, we found an interaction between memory performance and memory stage in brain regions associated with the default network, including the posteromedial cortex, posterior parietal cortex and parahippocampal cortex. We discuss these findings in relation to the encoding/retrieval flip. In general, the findings demonstrate that task-induced effects cut across intrinsic cortical networks. Furthermore, regions within the default network display functional dissociations and this may have implications for the neural underpinnings of age-related memory disorders.
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影响因子：
5.7
作者：
Daselaar, SM;Prince, SE;Cabeza, R
通讯作者：
Cabeza, R
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
DOI：
10.1523/jneurosci.3189-09.2009
发表时间：
2009-10-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hedden T;Van Dijk KR;Becker JA;Mehta A;Sperling RA;Johnson KA;Buckner RL
通讯作者：
Buckner RL
影响因子：
--
作者：
Allen, Greg;Barnard, Holly;Cullum, C. Munro
通讯作者：
Cullum, C. Munro