Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: experimental models and clinical perspectives.
Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: experimental models and clinical perspectives.
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DOI：
10.4161/cc.8.7.8075
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发表时间：
2009-04-01
期刊：
影响因子：
--
通讯作者：
Brown JM
中科院分区：
文献类型：
--
作者：
Ahn GO;Brown JM
在这篇综述中，我们重点介绍了一些最近的研究，这些研究强调了肿瘤微环境的重要性，特别是骨髓来源的髓样细胞在照射后恢复肿瘤生长中的作用。髓细胞是造血细胞，在外周血和组织中产生单核细胞和巨噬细胞。这些细胞已被证明在肿瘤中促进血管生成，促进肿瘤生长。我们还讨论了我们以前未发表的关于辐照对肿瘤血管系统的影响的结果，包括肿瘤血管内皮的周细胞和基底膜覆盖。我们总结了这些研究的临床意义，包括使用MMP-9抑制剂，给予白细胞增强剂，或规划肿瘤体积的安全边际，以提高接受放射治疗的癌症患者的总体临床效益。
In this review, we highlight some of recent studies underscoring the importance of the tumor microenvironment, especially the role of bone marrow-derived myeloid cells, in restoring tumor growth after irradiation. Myeloid cells are hematopoietic cells that give rise to monocytes and macrophages in the peripheral blood and tissues. These cells have been shown to be proangiogenic in tumors promoting tumor growth. We also discuss our previously unpublished results on the effect of irradiation on the tumor vasculature including pericyte and basement membrane coverage to the endothelium of tumor blood vessels. We summarize the clinical significance of these studies including the use of MMP-9 inhibitors, administering white blood cell boosters, or planning safety margin of tumor volumes, in order to improve overall clinical benefits in cancer patients treated with radiotherapy.
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影响因子：
3.6
作者：
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通讯作者：
Schwade, James G.
影响因子：
50.3
作者：
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通讯作者：
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20.1
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11.2
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作者：
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