Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.
Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.
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DOI:
10.1021/ja306637u
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发表时间:
2012-09-12
影响因子:
15
通讯作者:
Danishefsky SJ
中科院分区:
文献类型:
--
作者:
Dong S;Shang S;Li J;Tan Z;Dean T;Maeda A;Gardella TJ;Danishefsky SJ
Application of chemical synthesis to gain access to high purity hPTH as well as more stable analogs was accomplished through a menu of extended NCL followed by metal free dethiylation.
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