The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS).
The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS).
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DOI：
10.1007/s00125-012-2741-8
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发表时间：
2013-01
期刊：
影响因子：
8.2
通讯作者：
Hanley, A. J.
中科院分区：
文献类型：
--
作者：
Lee, C. C.;Lorenzo, C.;Haffner, S. M.;Wagenknecht, L. E.;Festa, A.;Goodarzi, M. O.;Stefanovski, D.;Olson, N. C.;Norris, J. M.;Rewers, M. J.;Hanley, A. J.
关键词：
胰岛素清除率下降可能是胰岛素敏感性恶化的早期代偿机制。然而，之前没有研究调查亚临床炎症或纤维蛋白溶解受损与胰岛素清除率的关系。我们研究了纤溶酶原激活物抑制剂(PAI)-1、c反应蛋白（CRP）、肿瘤坏死因子(TNF)-α、瘦素和纤维蛋白原与胰岛素代谢清除率（MCRI）随时间的进展之间的关系。我们在胰岛素抵抗动脉粥样硬化研究（IRAS）中研究了784名非糖尿病白种人、西班牙裔和非裔美国人。胰岛素敏感性（SI）、急性胰岛素反应（AIR）和MCRI在基线和5年随访时通过频繁采样的静脉葡萄糖耐量试验来确定。基线时空腹血浆中检测炎症蛋白和纤溶蛋白。MCRI在5年随访中显著下降了29%。在多变量调整回归模型中，我们观察到血浆PAI-1升高与MCRI下降之间存在显著关联（β= - 0.045[- 0.081, - 0.0091]）。在未调整的模型中，较高的血浆CRP和瘦素与MCRI下降相关，然而，在调整体重指数和腰围后，这些关联不显著（CRP = - 0.016[- 0.041, 0.0083]，瘦素= - 0.044[- 0.10,0.011]）。在未调整的模型中，血浆TNF-α升高与MCRI下降相关（β= - 0.071[- 0.14, - 0.00087]），但在多变量调整模型中则无相关（β= - 0.056[- 0.13, 0.017]）。血浆纤维蛋白原与MCRI变化无关。我们发现，高血浆PAI-1（而不是CRP、TNF-α、瘦素或纤维蛋白原）独立地预测了IRAS多种族队列中胰岛素清除率的进行性下降。
Insulin clearance may decline as an early compensatory mechanism to deteriorating insulin sensitivity. However, no previous studies have investigated the association of subclinical inflammation or impaired fibrinolysis with insulin clearance. We examined the association between plasminogen activator inhibitor (PAI)-1, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, leptin and fibrinogen and the progression of metabolic clearance rate of insulin (MCRI) over time. We studied 784 non-diabetic Caucasians, Hispanics and African-Americans in the Insulin Resistance Atherosclerosis Study (IRAS). Insulin sensitivity (SI), acute insulin response (AIR) and MCRI were determined from frequently sampled intravenous glucose tolerance tests at baseline and at 5-year follow-up. Inflammatory and fibrinolytic proteins were measured in fasting plasma at baseline. MCRI declined significantly by 29% in 5-year follow-up. We observed a significant association between higher plasma PAI-1 and the decline in MCRI in multivariable-adjusted regression models (β= −0.045 [−0.081, −0.0091]). Higher plasma CRP and leptin were associated with a decline in MCRI in unadjusted models, however, these associations were non-significant after adjusting for body mass index and waist circumference (β= −0.016 [−0.041, 0.0083] for CRP, β= −0.044 [−0.10, 0.011] for leptin). Higher plasma TNF-α was associated with a decline in MCRI in unadjusted (β= −0.071 [−0.14, −0.00087]), but not in multivariable-adjusted (β= −0.056 [−0.13, 0.017]) models. Plasma fibrinogen was not associated with the change in MCRI. We identified that higher plasma PAI-1 (but not CRP, TNF-α, leptin or fibrinogen) independently predicts the progressive decline of insulin clearance in the multi-ethnic cohort of the IRAS.
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影响因子：
3.7
作者：
Gkrania-Klotsas E;Ye Z;Cooper AJ;Sharp SJ;Luben R;Biggs ML;Chen LK;Gokulakrishnan K;Hanefeld M;Ingelsson E;Lai WA;Lin SY;Lind L;Lohsoonthorn V;Mohan V;Muscari A;Nilsson G;Ohrvik J;Chao Qiang J;Jenny NS;Tamakoshi K;Temelkova-Kurktschiev T;Wang YY;Yajnik CS;Zoli M;Khaw KT;Forouhi NG;Wareham NJ;Langenberg C
通讯作者：
Langenberg C
影响因子：
8.2
作者：
Lee, C. C.;Adler, A. I.;Wareham, N. J.
通讯作者：
Wareham, N. J.
影响因子：
10.4
作者：
Juhan-Vague, I;Alessi, MC;Morange, PE
通讯作者：
Morange, PE
影响因子：
8.7
作者：
Festa, A;D'Agostino, R;Haffner, SM
通讯作者：
Haffner, SM
DOI：
10.1161/01.atv.10.2.223
发表时间：
1990-03-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
LAAKSO, M;SARLUND, H;MYKKANEN, L
通讯作者：
MYKKANEN, L