Plasticity and specificity of the circadian epigenome.
Plasticity and specificity of the circadian epigenome.
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DOI：
10.1038/nn.2668
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发表时间：
2010-11
影响因子：
25
通讯作者：
Sassone-Corsi, Paolo
中科院分区：
文献类型：
--
作者：
Masri, Selma;Sassone-Corsi, Paolo
生物钟通过基因组的重要部分的转录调节来控制各种神经元、行为和生理反应。我们描述了大脑特定的中央时钟和组织特定的外围时钟之间的复杂通信网络，这些时钟用于同步生物体的外部和内部需求。此外，我们讨论和推测表观遗传过程是如何参与创造转录环境，允许组织特异性的基因表达程序，这与昼夜节律机制。积累的数据表明，染色质重塑事件可能是至关重要的提供特异性和可塑性的昼夜节律调节，和代谢线索可能参与指导这样的表观遗传事件。详细了解中央和外围时钟之间的通信线索对于更完整地理解昼夜节律系统和维持生物计时所涉及的多层次控制至关重要。
Circadian clocks control a variety of neuronal, behavioral and physiological responses, via transcriptional regulation of a significant portion of the genome. We describe the complex communication network between the brain-specific central clock and the tissue-specific peripheral clocks that serve to synchronize the organism to both external and internal demands. In addition, we discuss and speculate how epigenetic processes are involved in creating transcriptional environments that are permissive to tissue-specific gene expression programs, which work in concert with the circadian machinery. Accumulating data shows that chromatin remodeling events may be critical for providing specificity and plasticity in circadian regulation, and metabolic cues may be involved in directing such epigenetic events. A detailed understanding of the communication cues between the central and peripheral clocks is crucial for a more complete understanding of the circadian system and the multiple levels of control that are implicated in maintaining biological timekeeping.
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