The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells.
The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells.
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DOI：
10.1016/j.virol.2010.10.016
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发表时间：
2011-01-20
期刊：
影响因子：
3.7
通讯作者：
Brinton MA
中科院分区：
文献类型：
--
作者：
Elbahesh H;Jha BK;Silverman RH;Scherbik SV;Brinton MA
Resistance to flavivirus-induced disease in mice is conferred by the autosomal gene Flv, identified as 2′-5′ oligoadenylate synthetase 1b (Oas1b). Resistant mice express a full-length Oas1b protein while susceptible mice express the truncated Oas1btr. In this study, Oas1b was shown to be an inactive synthetase. Although the Oas/RNase L pathway was previously shown to have an antiviral role during flavivirus infections, Oas1b protein inhibited Oas1a in vitro synthetase activity in a dose-dependent manner and reduced 2-5A production in vivo in response to poly(I:C). These findings suggest that negative regulation of 2-5A by inactive Oas1 proteins may fine tune the RNase L response that if not tightly controlled could cause significant damage in cells. The results also indicate that flavivirus resistance conferred by Oas1b is not mediated by 2-5A. Instead, Oas1b inhibits flavivirus replication by an alternative mechanism that overrides the proviral effect of reducing 2-5A accumulation and RNase L activation.
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DOI：
10.1046/j.1432-1327.1998.2570319.x
发表时间：
1998-10-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Rebouillat, D;Marié, I;Hovanessian, AG
通讯作者：
Hovanessian, AG
影响因子：
4.8
作者：
Hartmann, R;Norby, PL;Justesen, J
通讯作者：
Justesen, J
影响因子：
3.7
作者：
Scherbik, Svetlana V.;Kluetzman, Kerri;Brinton, Margo A.
通讯作者：
Brinton, Margo A.
影响因子：
5.4
作者：
Maitra, RK;Silverman, RH
通讯作者：
Silverman, RH
影响因子：
16
作者：
Hartmann, R;Justesen, J;Yee, VC
通讯作者：
Yee, VC