Role of nitric oxide in management of acute respiratory distress syndrome.

Role of nitric oxide in management of acute respiratory distress syndrome.
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DOI:
10.4103/1817-1737.41914
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发表时间:
2008-07
影响因子:
2.3
通讯作者:
Hasan M
Hasan M
中科院分区:
医学4区
文献类型:
--
作者:
Akmal AH;Hasan M

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目前,急性呼吸窘迫综合征(ARDS)患者的死亡率在45%至92%之间,大多数人在患病后头两周内死亡。为了应对如此惊人的高死亡率,人们尝试了各种治疗方法,如低潮气量机械通气策略、皮质类固醇治疗和一氧化氮(NO)的使用等。3例住进ICU并确诊为ARDS的患者无法脱离呼吸机支持,开始了一氧化氮治疗。短期改善患者氧合,但不影响病死率。患者无法脱离呼吸机,因此生命垂危。
The current mortality rate of patients suffering from acute respiratory distress syndrome (ARDS) is between 45% and 92%, with most dying within the first two weeks of the illness. In an effort to combat such an alarmingly high mortality rate, various treatment therapies such as low tidal volume ventilation strategies, corticosteroid therapy, and use of nitric oxide (NO) have been attempted in the management of patients with ARDS. Three cases which were admitted to the ICU and confirmed to have ARDS were unable to be weaned from ventilatory support, and nitric oxide therapy was initiated. It improved patients' oxygenation for short periods of time but did not affect the mortality. The patients could not be weaned from the ventilator and expired.
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