Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent.
Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent.
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DOI：
10.1371/journal.pone.0043067
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Sulik KK
中科院分区：
文献类型：
--
作者：
Lipinski RJ;Hammond P;O'Leary-Moore SK;Ament JJ;Pecevich SJ;Jiang Y;Budin F;Parnell SE;Suttie M;Godin EA;Everson JL;Dehart DB;Oguz I;Holloway HT;Styner MA;Johnson GA;Sulik KK
产前酒精暴露是先天性精神残疾的主要可预防原因。而胎儿酒精综合征（FAS）的诊断需要确定一个特定的模式颅面畸形，大多数人的行为和神经系统后遗症的产前酒精暴露不表现出这些定义的面部特征。在这里，一种新的整合MRI和密集的表面建模为基础的形状分析被应用于表征并发的面脑表型在C57 Bl/6 J胎儿暴露于乙醇在妊娠第7天（GD）或GD 8.5。酒精暴露导致的面部表型取决于损伤的阶段，并预测相应的大脑异常的独特模式。GD 7乙醇暴露产生了一系列人类FAS特有的畸形面部特征，包括重度面中部发育不全、睑裂缩短、上唇延长和人中缺陷。相比之下，乙醇暴露于GD8.5导致轻度面中部发育不全和睑裂缩短，上唇缩短，人中保留。这些不同的，阶段特异性的面部表型与独特的体积和形状异常的隔区，垂体和嗅球。通过证明早期产前乙醇暴露可导致一种以上的时间特异性缺陷模式，这些发现说明需要扩大目前的诊断标准，以更好地捕捉胎儿酒精谱系障碍的全方位面部和大脑畸形。
Prenatal ethanol exposure is the leading preventable cause of congenital mental disability. Whereas a diagnosis of fetal alcohol syndrome (FAS) requires identification of a specific pattern of craniofacial dysmorphology, most individuals with behavioral and neurological sequelae of heavy prenatal ethanol exposure do not exhibit these defining facial characteristics. Here, a novel integration of MRI and dense surface modeling-based shape analysis was applied to characterize concurrent face-brain phenotypes in C57Bl/6J fetuses exposed to ethanol on gestational day (GD)7 or GD8.5. The facial phenotype resulting from ethanol exposure depended upon stage of insult and was predictive of unique patterns of corresponding brain abnormalities. Ethanol exposure on GD7 produced a constellation of dysmorphic facial features characteristic of human FAS, including severe midfacial hypoplasia, shortening of the palpebral fissures, an elongated upper lip, and deficient philtrum. In contrast, ethanol exposure on GD8.5 caused mild midfacial hypoplasia and palpebral fissure shortening, a shortened upper lip, and a preserved philtrum. These distinct, stage-specific facial phenotypes were associated with unique volumetric and shape abnormalities of the septal region, pituitary, and olfactory bulbs. By demonstrating that early prenatal ethanol exposure can cause more than one temporally-specific pattern of defects, these findings illustrate the need for an expansion of current diagnostic criteria to better capture the full range of facial and brain dysmorphology in fetal alcohol spectrum disorders.
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影响因子：
2
作者：
Hammond, P;Hutton, TJ;Winter, RM
通讯作者：
Winter, RM
影响因子：
10.6
作者：
Hutton, TJ;Buxton, BF;Potts, HWW
通讯作者：
Potts, HWW
DOI：
10.1001/archpedi.1982.03970460036008
发表时间：
1982-01-01
影响因子：
--
作者：
AMMANN, AJ;WARA, DW;STIEHM, ER
通讯作者：
STIEHM, ER
DOI：
10.1176/appi.neuropsych.16.1.41
发表时间：
2004-12-01
影响因子：
2.9
作者：
Galarza, M;Merlo, AB;Albanese, AM
通讯作者：
Albanese, AM
DOI：
10.1111/j.1530-0277.2011.01465.x
发表时间：
2011-07
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Chen Y;Ozturk NC;Ni L;Goodlett C;Zhou FC
通讯作者：
Zhou FC