Slowing of intestinal transit by fat depends on naloxone-blockable efferent, opioid pathway.
Slowing of intestinal transit by fat depends on naloxone-blockable efferent, opioid pathway.
复制标题
脂肪对肠道转运的减慢取决于纳洛酮可阻断的传出阿片途径。
DOI：
10.1152/ajpgi.2000.278.6.g866
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Lin,HC
中科院分区：
文献类型：
--
作者：
Zhao,XT;Wang,L;Lin,HC
远端肠道中的脂肪减缓通过近端小肠的传输称为回肠制动。静脉注射阿片受体拮抗剂纳洛酮，取消脂肪诱导的回肠制动，表明内源性阿片途径可能参与了这一反应。为了检验这一假设，即肠道远侧半部分的脂肪减缓肠道转运取决于位于该反应传出支上的阿片途径，我们比较了患有十二指肠和中肠瘘的犬的肠道转运，同时将纳洛酮与油酸盐分隔到肠道远侧半部分或与缓冲液分隔到肠道近侧半部分。我们发现肠转运依赖于灌注条件（P< 0.00001）。具体而言，与回肠制动（标记物恢复率为35.7 ± 7.4%）相比，当纳洛酮递送至近端一半肠道（76.2 ± 5.2%）（P< 0.005）而非远端一半肠道（29.4 ± 5.4%）时，肠道传输加速。我们的结论是，肠转运的脂肪在远端一半的肠道依赖于位于回肠制动的传出肢体阿片途径。
Slowing of transit through the proximal small intestine by fat in the distal gut is termed the ileal brake. Intravenous naloxone, an opioid receptor antagonist, abolished the fat-induced ileal brake, suggesting that an endogenous opioid pathway may be involved in this response. To test the hypothesis that slowing of intestinal transit by fat in the distal half of the gut depends on an opioid pathway located on the efferent limb of this response, we compared intestinal transit in dogs equipped with duodenal and midgut fistulas while naloxone was either compartmentalized with oleate to the distal half of the gut or with buffer to the proximal half of the gut. We found that intestinal transit depended on the perfusion conditions (P< 0.00001). Specifically, compared with ileal brake (marker recovery of 35.7 ± 7.4%), intestinal transit was accelerated when naloxone was delivered into the proximal half of the gut (76.2 ± 5.2%) (P< 0.005) but not the distal half of the gut (29.4 ± 5.4%). We conclude that slowing of intestinal transit by fat in the distal half of the gut depends on an opioid pathway located on the efferent limb of the ileal brake.
登录
查看更多内容
影响因子：
29.4
作者：
I. Taylor
通讯作者：
I. Taylor
纳洛酮的药代动力学：深入了解应激性溃疡的作用部位。
影响因子：
3.5
作者：
R. Kleiman;C. G. Adair;K. Ephgrave
通讯作者：
K. Ephgrave
自主神经系统中的强啡肽免疫反应性神经元
影响因子：
3.3
作者：
S. Vincent;C. Dalsgaard;M. Schultzberg;T. Hökfelt;I. Christensson;L. Terenius
通讯作者：
L. Terenius
人肠道中的 Met5-脑啡肽-Arg6-Gly7-Leu8 免疫反应性
影响因子：
3
作者：
G. Ferri;Rosalba A. Morreale;G. Dockray
通讯作者：
G. Dockray
外源性阿片类药物：它们在犬小肠和胃中的局部作用机制。
影响因子：
--
作者：
J. Fox;E. Daniel
通讯作者：
E. Daniel