Expression of nestin in Purkinje cells in patients with Creutzfeldt-Jakob disease
Expression of nestin in Purkinje cells in patients with Creutzfeldt-Jakob disease
复制标题
克雅氏病患者浦肯野细胞巢蛋白的表达
DOI：
10.1016/j.neulet.2003.08.056
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发表时间：
2003
影响因子：
2.5
通讯作者：
K. Okamoto
中科院分区：
文献类型：
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作者：
Y. Mizuno;T. Takeuchi;M. Takatama;K. Okamoto
巢蛋白是中间丝蛋白之一，主要在中枢神经系统发育过程中表达。我们使用抗人巢蛋白抗体检查了克雅氏病 (CJD)、多系统萎缩和肌萎缩侧索硬化症患者的小脑。这些抗体对克雅氏病浦肯野细胞的细胞质、树突和鱼雷体进行了强烈的免疫染色。然而，其他神经退行性疾病中的浦肯野细胞不具有巢蛋白免疫反应性。随着小脑病理严重程度的增加，巢蛋白免疫反应性变得更加明显。我们的研究结果表明，巢蛋白在病理性晚期克雅氏病的浦肯野细胞中强烈表达，并表明浦肯野细胞可能被重新激活以促进存活。
Nestin is one of the intermediate filament proteins and mainly expressed during the development of the central nervous system. We examined the cerebellum of patients with Creutzfeldt-Jakob disease (CJD), multiple system atrophy and amyotrophic lateral sclerosis, using anti-human nestin antibodies. The antibodies strongly immunostained the cytoplasm, dendrites and torpedoes of Purkinje cells in CJD. However, Purkinje cells in other neurodegenerative disorders were not nestin-immunoreactive. Nestin immunoreactivities became more marked as the pathological severity in the cerebellum increased. Our findings suggest that nestin is strongly expressed in Purkinje cells in pathologically advanced CJD and show the possibility that Purkinje cells are being reactivated to promote survival.
DOI：
--
发表时间：
1992-03
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
T. Tohyama;V. Lee;L. Rorke;M. Marvin;R. McKay;J. Trojanowski
通讯作者：
T. Tohyama;V. Lee;L. Rorke;M. Marvin;R. McKay;J. Trojanowski