Oxygen-induced retinopathy in the rat.
Oxygen-induced retinopathy in the rat.
复制标题
氧诱导的大鼠视网膜病变。
DOI：
10.1007/978-1-4684-5568-7_168
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Thum,LA
中科院分区：
文献类型：
--
作者：
Penn,JS;Thum,LA
Through a decade of research, peroxidation has been implicated in human retinal degenerations. Ocular siderosis, or iron in the eye, has long been known to result in retinal degeneration. Certain retinotoxic drugs, such as adriamycin, are believed to act by peroxidative mechanisms. The retina can also be damaged by excess light, presumably through photo-oxidative processes. Senile macular degeneration is yet another candidate for peroxidation-induced degeneration. Finally, retinopathy of prematurity occurs only in premature infants housed in elevated levels of atmospheric oxygen. Although the agent in each of these insults may be different, cell destruction and death apparently proceed through pathways common to lipid or protein oxidation.
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