Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice.
Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice.
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DOI：
10.1002/bies.201400066
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发表时间：
2014-09
期刊：
影响因子：
4
通讯作者：
Repasky, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Messmer, Michelle N.;Kokolus, Kathleen M.;Eng, Jason W. -L.;Abrams, Scott I.;Repasky, Elizabeth A.
生理学上准确的小鼠癌症模型对于新型癌症疗法的临床前开发至关重要。然而，目前标准化的动物饲养温度会引起小鼠慢性寒冷相关应激，在肿瘤存在时这种应激会进一步增加。这种冷应激显着影响实验结果。我们实验室和其他实验室的数据表明，标准住房从根本上改变了小鼠的生理机能，这可能会导致肿瘤和其他疾病模型中的免疫基线发生改变。因此，研究人员可能低估了受益于免疫反应的疗法的功效。去甲肾上腺素是一种潜在的介质，也是小鼠和人类常见的应激途径的基础。因此，对小鼠冷应激和去甲肾上腺素信号传导与免疫抑制之间联系的机制的研究可以为人类提供新的联合疗法，以在刺激抗肿瘤免疫力的同时针对压力。
Physiologically accurate mouse models of cancer are critical in the pre-clinical development of novel cancer therapies. However, current standardized animal-housing temperatures elicit chronic cold-associated stress in mice, which is further increased in the presence of tumor. This cold-stress significantly impacts experimental outcomes. Data from our lab and others suggests standard housing fundamentally alters murine physiology, and this can produce altered immune baselines in tumor and other disease models. Researchers may thus underestimate the efficacy of therapies that are benefitted by immune responses. A potential mediator, norepinephrine, also underlies stress pathways common in mice and humans. Therefore, research into mechanisms connecting cold-stress and norepinephrine signaling with immune-depression in mice could highlight new combination therapies for humans to simultaneously target stress while stimulating anti-tumor immunity.
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DOI：
10.1523/jneurosci.4671-10.2011
发表时间：
2011-02-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
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DOI：
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发表时间：
2009-07-01
影响因子：
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影响因子：
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作者：
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