Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis.
Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis.
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DOI：
10.1016/j.bbi.2014.12.007
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发表时间：
2015-05
影响因子：
15.1
通讯作者：
Lovett-Racke, Amy E.
中科院分区：
文献类型：
--
作者：
Lee, Priscilla W.;Yang, Yuhong;Racke, Michael K.;Lovett-Racke, Amy E.
关键词：
The phenotype of the CD4+ T cells that mediate the CNS pathology in multiple sclerosis is still unclear, and yet a vital question for developing therapies. One of the conundrums is the role of TGF-β in the development of encephalitogenic Th17 cells. In the present study, TGF-β1 and TGF-β3 were directly compared in their capacity to promote the differentiation of myelin-specific Th17 cells that could induce experimental autoimmune encephalomyelitis (EAE). Myelin-specific CD4+ T cell receptor transgenic cells differentiated with antigen in the presence of IL-6+TGF-β1 or IL-6+TGF-β3 generated T cells that produced robust amounts of IL-17, but were incapable of inducing EAE when transferred into mice. Further analysis of these non-encephalitogenic Th17 cells found that they expressed lower amounts of GM-CSF or IL-23R, both molecules necessary for encephalitogenicity. Thus, TGF-β, irrespective of isoform, negatively regulates the differentiation of encephalitogenic Th17 cells.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
4.4
作者：
Pelfrey, CM;Rudick, RA;Lehmann, PV
通讯作者：
Lehmann, PV
影响因子：
3.3
作者：
JOHNS, LD;SRIRAM, S
通讯作者：
SRIRAM, S
影响因子：
30.5
作者：
通讯作者：
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DOI：
10.4049/jimmunol.1000288
发表时间：
2010-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Huss DJ;Winger RC;Peng H;Yang Y;Racke MK;Lovett-Racke AE
通讯作者：
Lovett-Racke AE