Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia.
Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia.
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人类血浆的多组学揭示了精神分裂症中炎症失调和加速衰老的分子特征。
DOI：
10.1038/s41380-021-01339-z
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发表时间：
2022-03
影响因子：
11
通讯作者：
Hook, Vivian
中科院分区：
文献类型：
--
作者：
Campeau, Anaamika;Mills, Robert H.;Stevens, Toer;Rossitto, Leigh-Ana;Meehan, Michael;Dorrestein, Pieter;Daly, Rebecca;Nguyen, Tanya T.;Gonzalez, David J.;Jeste, Dilip, V;Hook, Vivian
精神分裂症是一种毁灭性的精神疾病，在精神上影响着世界人口的很大一部分。精神分裂症患者的老龄化与寿命缩短有关，但尚未在全球范围内研究与该人群老龄化相关的潜在生物学因素。为了解决这一知识差距，本研究评估了患有精神分裂症的受试者血浆中的蛋白质组学和代谢组学特征，并与60多年的非精神病对照患者进行了比较。对循环血浆进行全面、无偏倚的分析可以提供关于显著失调的分子途径及其与精神分裂症的关联以及这种疾病的年龄和性别特征的知识。在这项研究中汇编的结果数据代表了人类一生中与精神分裂症相关的分子变化的概要。支持精神分裂症与更快衰老相关的临床发现，精神分裂症诊断和年龄显著影响受试者的血浆蛋白质组。精神分裂症与炎症和代谢系统成分的显著失调广泛相关。蛋白质组的变化表明，精神分裂症的生理性共病风险的生物标志物的丰度增加，特别是在年轻个体中。这些发现推进了我们对精神分裂症的分子病因学及其在整个衰老过程中的相关共病的理解。
Schizophrenia is a devastating psychiatric illness that detrimentally affects a significant portion of the worldwide population. Aging of schizophrenia patients is associated with reduced longevity, but the potential biological factors associated with aging in this population have not yet been investigated in a global manner. To address this gap in knowledge, the present study assesses proteomics and metabolomics profiles in the plasma of subjects afflicted with schizophrenia compared to non-psychiatric control patients over six decades of life. Global, unbiased analyses of circulating blood plasma can provide knowledge of prominently dysregulated molecular pathways and their association with schizophrenia, as well as features of aging and gender in this disease. The resulting data compiled in this study represent a compendium of molecular changes associated with schizophrenia over the human lifetime. Supporting the clinical finding of schizophrenia’s association with more rapid aging, both schizophrenia diagnosis and age significantly influenced the plasma proteome in subjects assayed. Schizophrenia was broadly associated with prominent dysregulation of inflammatory and metabolic system components. Proteome changes demonstrated increased abundance of biomarkers for risk of physiologic comorbidities of schizophrenia, especially in younger individuals. These findings advance our understanding of the molecular etiology of schizophrenia and its associated comorbidities throughout the aging process.
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影响因子：
7.8
作者：
Jo-Watanabe A;Ohse T;Nishimatsu H;Takahashi M;Ikeda Y;Wada T;Shirakawa J;Nagai R;Miyata T;Nagano T;Hirata Y;Inagi R;Nangaku M
通讯作者：
Nangaku M
影响因子：
4.3
作者：
Hill SK;Bishop JR;Palumbo D;Sweeney JA
通讯作者：
Sweeney JA
影响因子：
7
作者：
Kilbourne, Amy M.;Morden, Nancy E.;Blow, Frederic C.
通讯作者：
Blow, Frederic C.
影响因子：
5.4
作者：
Akinkuolie, Akintunde O.;Buring, Julie E.;Mora, Samia
通讯作者：
Mora, Samia
影响因子：
4
作者：
Boiko, Anastasiia S.;Mednova, Irina A.;Ivanova, Svetlana A.
通讯作者：
Ivanova, Svetlana A.