Influence of vascular endothelial growth factor variation on human hippocampus morphology.
Influence of vascular endothelial growth factor variation on human hippocampus morphology.
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DOI：
10.1016/j.biopsych.2008.07.003
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发表时间：
2008-11-15
影响因子：
10.6
通讯作者：
Gelernter, Joel
中科院分区：
文献类型：
--
作者：
Blumberg, Hilary P.;Wang, Fei;Chepenik, Lara G.;Kalmar, Jessica H.;Edmiston, Elliot Kale;Duman, Ronald S.;Gelernter, Joel
关键词：
海马体的形态异常与神经精神疾病有关，包括抑郁症、精神分裂症和痴呆。血管内皮生长因子（VEGF）已被证明在大鼠海马中具有神经原性作用。然而，VEGF变异对人类海马形态学的影响尚未得到证实。在这里，一个综合的遗传和神经影像学方法被用来调查是否VEGF的变化影响人类海马形态。采用高分辨率磁共振成像和基于体素的形态计量学方法，研究了47名健康个体VEGFA基因[rs 833068（SNP-1）、rs 833070（SNP-2）、rs 2146323（SNP-3）和rs3025020（SNP-4）]的遗传变异对脑形态学的影响。VEGFA SNP-2和SNP-3的变异对海马浓度有显著影响。研究结果表明，VEGF在大鼠海马中的作用延伸到人类;进一步了解VEGFA变异的影响可能对识别更容易受到海马病理影响的个体以及最有可能从VEGF介导的干预中受益的神经精神人群具有重要意义。
Morphological abnormalities in hippocampus have been implicated in neuropsychiatric disorders, including depression, schizophrenia and dementia. Vascular endothelial growth factor (VEGF) has been demonstrated to have neurogenic effects in the hippocampus in rats. However, influence of VEGF variation on hippocampus morphology in humans has yet to be shown. Here, an integrated genetic and neuroimaging approach was used to investigate whether VEGF variation influences hippocampus morphology in humans. High-resolution magnetic resonance imaging and voxel-based morphometry were used to identify the influence of genetic variation of VEGFA [rs833068 (SNP-1), rs833070 (SNP-2), rs2146323 (SNP-3) and rs3025020 (SNP-4)] on brain morphology in forty-seven healthy individuals. Variation in VEGFA SNP-2 and SNP-3 showed significant effects on hippocampus concentration. The findings suggest that effects of VEGF in hippocampus found in rats extend to humans; further understanding of effects of VEGFA variation may have important implications in identifying individuals more vulnerable to hippocampus pathology, as well as those neuropsychiatric populations most likely to benefit from VEGF-mediated interventions.
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影响因子：
2.3
作者：
Tang, Yanqing;Wang, Fei;Blumberg, Hilary P.
通讯作者：
Blumberg, Hilary P.
DOI：
10.1073/pnas.97.18.10242
发表时间：
2000-08-29
影响因子：
11.1
作者：
Jin, KL;Mao, XO;Greenberg, DA
通讯作者：
Greenberg, DA
DOI：
10.1073/pnas.0610282104
发表时间：
2007-03-13
影响因子：
11.1
作者：
Warner-Schmidt, Jennifer L.;Duman, Ronald S.
通讯作者：
Duman, Ronald S.
DOI：
10.1073/pnas.182296499
发表时间：
2002-09-03
影响因子：
11.1
作者：
Jin, KL;Zhu, YH;Greenberg, DA
通讯作者：
Greenberg, DA
影响因子：
5.3
作者：
McCloskey, DP;Croll, SD;Scharfman, HE
通讯作者：
Scharfman, HE