Concepts and methods for the study of axonal regeneration in the CNS.

Concepts and methods for the study of axonal regeneration in the CNS.
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DOI:
10.1016/j.neuron.2012.05.006
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发表时间:
2012-06-07
期刊:
影响因子:
16.2
通讯作者:
Steward O
Steward O
中科院分区:
医学1区
文献类型:
--
作者:
Tuszynski MH;Steward O

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轴突再生研究领域的进展就像轴突生长本身的过程一样:在到达目标的过程中有稳定的进展,但也有错误的目标,沿着沿着错误路线的错误引导,以及后来必须撤回的连接。本书将讨论中枢神经系统损伤后轴突生长研究中的问题,试图为该领域的进展目标提供指导。我们解决轴突生长,发芽和损伤后再生的定义,以及评估生长的研究工具。
Progress in the field of axonal regeneration research has been like the process of axonal growth itself: there is steady progress toward reaching the target, but there are episodes of mis-targeting, mis-guidance along false routes, and connections that must later be withdrawn. This primer will address issues in the study of axonal growth after central nervous system injury in an attempt to provide guidance toward the goal of progress in the field. We address definitions of axonal growth, sprouting and regeneration after injury, and the research tools to assess growth.
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