Whole-body (18)F-fluorodeoxyglucose positron emission tomography in patients with head and neck cancer.
Whole-body (18)F-fluorodeoxyglucose positron emission tomography in patients with head and neck cancer.
复制标题
头颈癌患者的全身 (18)F-氟脱氧葡萄糖正电子发射断层扫描。
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Y. Yonekura
中科院分区：
文献类型：
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作者：
Y. Kitagawa;S. Nishizawa;K. Sano;N. Sadato;Y. Maruta;T. Ogasawara;Mikiko Nakamura;Y. Yonekura
目的
由于继发原发性恶性肿瘤的高风险，除了可能的远处转移，全身评估是非常重要的头颈部癌症患者。我们评估了初始治疗前全身（18）F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）的临床实用性。
研究设计
我们在初步治疗前对26例头颈部癌症患者（鳞状细胞癌，n = 20;唾液腺癌，n = 6）进行了全身FDG PET。前瞻性评价FDG图像，如果需要，进行进一步的成像研究。通过分析手术标本的病理结果或分析1年以上的临床随访数据，最终诊断是否存在远处病变。
结果
PET显像显示3例（11.5%）FDG阳性病灶远离头颈部。2例确诊为继发性原发癌（1例为早期结肠癌，另1例为结肠癌术后肺小转移）。他们都得到了正确的诊断和治疗头颈癌和继发原发癌。1例患者确诊为头颈部癌大面积肺转移，选择了适当的治疗方案。
结论
全身FDG PET通过检测继发性原发性恶性肿瘤以及远处转移对头颈部癌症患者的管理具有临床影响。
OBJECTIVE
Because of the high risk of secondary primary malignancies in addition to possible distant metastases, whole-body evaluation is critically important in patients with head and neck cancer. We evaluated the clinical usefulness of whole-body (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) before initial treatment.
STUDY DESIGN
We performed whole-body FDG PET in 26 patients with head and neck cancer (squamous cell carcinoma, n = 20; salivary gland carcinoma, n = 6) before initial treatment. FDG images were prospectively evaluated, and further imaging studies were performed if required. Final diagnosis for the presence or absence of distant lesions was made by analysis of the pathologic findings of surgical specimens or by analysis of the clinical follow-up data for more than 1 year.
RESULTS
PET images showed FDG avid lesions distant from the head and neck area in 3 of 26 patients (11.5%). Two patients were confirmed to have secondary primary cancer (one with colon cancer in the early stage and another with small lung metastasis from postoperative colon cancer). They were diagnosed and treated properly both for the head and neck cancer and the secondary primary cancer. One patient was confirmed to have large lung metastasis from head and neck cancer, and appropriate treatment was selected.
CONCLUSIONS
Whole-body FDG PET has a clinical impact on the management of patients with head and neck cancer by detecting secondary primary malignancies as well as distant metastases.
DOI：
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发表时间：
1991-04
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
L. Strauss;P. Conti
通讯作者：
L. Strauss;P. Conti