Borderline Personality Disorder: Bipolarity, Mood Stabilizers and Atypical Antipsychotics in Treatment
Borderline Personality Disorder: Bipolarity, Mood Stabilizers and Atypical Antipsychotics in Treatment
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边缘性人格障碍：双相情感障碍、情绪稳定剂和非典型抗精神病药物的治疗
DOI：
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
M. Akbudak
中科院分区：
文献类型：
--
作者：
H. Belli;C. Ural;M. Akbudak
本文旨在综述心境稳定剂和非典型抗精神病药在双相和边缘型人格障碍的精神药理学治疗中的疗效。在此背景下，边缘性人格和双相情感障碍之间的共同现象学和临床诊断的区别特征将根据文献进行审查。这两种疾病在诊断方面可以表现出共同的特征，并且可以在现象上重叠。这两种疾病的并发率相当高。为了区分这两种疾病，应仔细考虑情绪波动的质量，冲动类型和疾病的线性进展。在边缘型人格障碍的治疗中，有各种关于情绪稳定剂使用的研究，如锂、卡马西平、奥卡西平、丙戊酸钠和拉莫三嗪。此外，也有研究显示利培酮、奥氮平和奎替鲁作为非典型抗精神病药物的疗效。将边缘型人格障碍与双相情感障碍区分开来并不容易。应进行深入细致的评估。这种区分可能对治疗也有帮助。关于丙戊酸钠和拉莫三嗪治疗边缘型人格障碍的疗效有很多研究。然而，与其他情绪稳定剂相关的发现是不够的。据报告，奥氮平和奎替鲁在非典型抗精神病药物中更有效。目前尚无药物被批准用于治疗边缘型人格障碍。心理治疗方法在边缘型人格障碍的治疗中保留了重要的地位。此外，在使用情绪稳定剂和非典型抗精神病药时，建议采用基于症状的方法。
In this article, it is aimed to review the efficacies of mood stabilizers and atypical antipsychotics, which are used commonly in psychopharmacological treatments of bipolar and borderline personality disorders. In this context, common phenomenology between borderline personality and bipolar disorders and differential features of clinical diagnosis will be reviewed in line with the literature. Both disorders can demonstrate common features in the diagnostic aspect, and can overlap phenomenologically. Concomitance rate of both disorders is quite high. In order to differentiate these two disorders from each other, quality of mood fluctuations, impulsivity types and linear progression of disorders should be carefully considered. There are various studies in mood stabilizer use, like lithium, carbamazepine, oxcarbazepine, sodium valproate and lamotrigine, in the treatment of borderline personality disorder. Moreover, there are also studies, which have revealed efficacies of risperidone, olanzapine and quetiapine as atypical antipsychotics. It is not easy to differentiate borderline personality disorder from the bipolar disorders. An intensively careful evaluation should be performed. This differentiation may be helpful also for the treatment. There are many studies about efficacy of valproate and lamotrigine in treatment of borderline personality disorder. However, findings related to other mood stabilizers are inadequate. Olanzapine and quetiapine are reported to be more effective among atypical antipsychotics. No drug is approved for the treatment of borderline personality disorder by the entitled authorities, yet. Psychotherapeutic approaches have preserved their significant places in treatment of borderline personality disorder. Moreover, symptom based approach is recommended in use of mood stabilizers and atypical antipsychotics.
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DOI：
10.1176/ajp.2007.164.6.929
发表时间：
2007-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
M. Zanarini;F. Frankenburg;D. B. Reich;K. Silk;J. Hudson;Lauren B. McSweeney
通讯作者：
M. Zanarini;F. Frankenburg;D. B. Reich;K. Silk;J. Hudson;Lauren B. McSweeney
影响因子：
4.8
作者：
Henry, C;Mitropoulou, V;Siever, LJ
通讯作者：
Siever, LJ
影响因子：
17.7
作者：
Koenigsberg, HW;Harvey, PD;Siever, LJ
通讯作者：
Siever, LJ
影响因子：
17.7
作者：
Gunderson, John G.;Weinberg, Igor;Dyck, Ingrid
通讯作者：
Dyck, Ingrid
影响因子：
5.4
作者：
Swann, AC;Dougherty, DM;Moeller, FG
通讯作者：
Moeller, FG