The value of single-pathogen antibacterial agents.
The value of single-pathogen antibacterial agents.
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DOI：
10.1038/nrd3957-c1
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发表时间：
2013-12
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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NA，不适用。*参考文献及方法说明见补充资料S1（表）。‡鲍曼不动杆菌每年感染人数乘以碳青霉烯类耐药病例的比例，也乘以发达国家生活人口占全球病例的比例。碳青霉烯耐药病例数乘以耐药成本；也乘以与美国相比的全球医疗保健费用。额外的耐药性费用乘以通过有效治疗而恢复的耐药性所造成的保健费用的百分比。耐碳青霉烯鲍曼杆菌病例总数乘以无效治疗导致的超额死亡率。#每年因耐药而导致的死亡人数乘以有效治疗后死亡率的超额降低。**挽救的每条生命的净成本等于净成本除以每年使用特定病原体治疗挽救的生命数量；每生命年节省的净成本等于每生命年节省的净成本除以每位患者通过有效治疗获得的平均生命年（表1）；每个质量调整生命年（QALY）的净成本等于每个生命年节省的净成本除以每年获得的平均生活质量。
NA, not applicable.* See Supplementary information S1 (table) for references and methodological description.‡ Number of A. baumannii infections per year multiplied by the proportion of carbapenem-resistant cases, also multiplied by the proportion of the global population living in a developed country for global cases. § Number of carbapenem-resistant cases multiplied by excess cost of resistance; for global cases, also multiplied by the global health-care costs compared to the United States.|| Excess cost of resistance multiplied by percent of health-care cost due to resistance recovered with effective therapy.¶ Total number of carbapenem-resistant A. baumannii cases multiplied by excess mortality attributable to ineffective therapy.# Deaths per year due to resistance without pathogenspecific therapy multiplied by excess mortality reduction with effective therapy.** Net cost per life saved is equal to the net cost divided by the number of lives saved per year with the pathogen-specific therapy; net cost per life year saved is equal to the net cost per life saved divided by the average life years gained with the effective therapy per patient (TABLE 1); the net cost per quality-adjusted life year (QALY) is equal to the net cost per life year saved divided by the average quality of life per year gained.
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影响因子：
158.5
作者：
Manns, BJ;Lee, H;Donaldson, C
通讯作者：
Donaldson, C
影响因子：
11.8
作者：
Guidos, Robert J.;Spellberg, Brad;Gilbert, David N.
通讯作者：
Gilbert, David N.
DOI：
10.1164/ajrccm.163.6.2005123
发表时间：
2001-05-01
影响因子：
24.7
作者：
Angus, DC;Musthafa, AA;Pinsky, MR
通讯作者：
Pinsky, MR
影响因子：
11.8
作者：
Spellberg, Brad;Brass, Eric P.;Gilbert, David N.
通讯作者：
Gilbert, David N.
影响因子：
56.3
作者：
Rex, John H.;Eisenstein, Barry I.;Jackson, Jennifer
通讯作者：
Jackson, Jennifer