A new developmental compartment in the forebrain regulated by Lunatic fringe
A new developmental compartment in the forebrain regulated by Lunatic fringe
复制标题
前脑中由疯狂边缘调节的新发育区室
DOI：
10.1038/89455
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发表时间：
2001
影响因子：
25
通讯作者：
A. Lumsden
中科院分区：
文献类型：
--
作者：
L. Zeltser;C. Larsen;A. Lumsden
我们在鸟类前脑中发现了一个隔间，其细胞谱系限制的边界包围了大约三分之一的早期前脑囊泡，定义了一个后来变窄形成丘脑内限制膜（zli）的区域。Lunatic fringe（L-fng）在隔室侧翼的结构域中表达，划定其前后边界;异位L-fng表达足以指导细胞从zli中分选出来，也可以破坏边界，防止zli形成。在前脑的其他地方缺乏类似的边缘边界，表明形成zli室的机制不同于前脑的拟议节段细分，前体。
We identified a compartment in the avian prosencephalon, whose cell-lineage-restricted borders enclose about one-third of the early prosencephalic vesicle, defining a region that later narrows to form the zona limitans intrathalamica (zli). Lunatic fringe (L-fng) is expressed in domains flanking the compartment, delineating its anterior and posterior borders; ectopic L-fng expression is sufficient to direct cells to sort out of the zli, and can also disrupt the borders, preventing zli formation. The lack of similarly oriented fringe borders elsewhere in the prosencephalon indicates that the mechanism for forming the zli compartment differs from that for the proposed segmental subdivisions of the forebrain, prosomeres.
影响因子：
56.9
作者：
V. Papayannopoulos;Andrew Tomlinson;Vladislav M. Panin;C. Rauskolb;Kenneth D. Irvine
通讯作者：
V. Papayannopoulos;Andrew Tomlinson;Vladislav M. Panin;C. Rauskolb;Kenneth D. Irvine