Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin.
Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin.
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DOI：
10.3390/biom12111549
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发表时间：
2022-10-24
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
CD4 T细胞在感染性疾病和癌症的情况下是阳性的，在自身免疫和过敏的情况下是阴性的，其影响的核心是它们分化成具有专门功能的不同效应子亚群的能力。支持这种反应所需的编程在很大程度上由谱系特异性转录因子决定，通常称为“主调节因子”。然而，越来越清楚的是，CD4 T细胞免疫生物学的许多方面可以决定疾病状态的结果，涉及更广泛的转录网络。Eomesodermin（Eomes）是这类转录因子的重要成员。虽然在CD8 T细胞和NK细胞中研究得最好，但越来越多的工作集中在一系列不同环境中Eomes表达对CD4 T细胞应答的影响。在这里，我们专注于这些研究中报告的各种影响，这些研究共同表明靶向CD4 T细胞中Eomes表达作为改善各种临床结果的策略的潜力。
Central to the impacts of CD4 T cells, both positive in settings of infectious disease and cancer and negative in the settings of autoimmunity and allergy, is their ability to differentiate into distinct effector subsets with specialized functions. The programming required to support such responses is largely dictated by lineage-specifying transcription factors, often called ‘master regulators’. However, it is increasingly clear that many aspects of CD4 T cell immunobiology that can determine the outcomes of disease states involve a broader transcriptional network. Eomesodermin (Eomes) is emerging as an important member of this class of transcription factors. While best studied in CD8 T cells and NK cells, an increasing body of work has focused on impacts of Eomes expression in CD4 T cell responses in an array of different settings. Here, we focus on the varied impacts reported in these studies that, together, indicate the potential of targeting Eomes expression in CD4 T cells as a strategy to improve a variety of clinical outcomes.
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影响因子：
7.3
作者：
通讯作者：
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DOI：
10.4049/jimmunol.1800396
发表时间：
2018-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Connors TJ;Baird JS;Yopes MC;Zens KD;Pethe K;Ravindranath TM;Ho SH;Farber DL
通讯作者：
Farber DL
影响因子：
6.7
作者：
Buggert M;Tauriainen J;Yamamoto T;Frederiksen J;Ivarsson MA;Michaëlsson J;Lund O;Hejdeman B;Jansson M;Sönnerborg A;Koup RA;Betts MR;Karlsson AC
通讯作者：
Karlsson AC
影响因子：
4.4
作者：
Broux, Bieke;Mizee, Mark R.;Hellings, Niels
通讯作者：
Hellings, Niels
影响因子：
4.4
作者：
Dhume, Kunal;Finn, Caroline M.;Devarajan, Priyadharshini;Singh, Ayushi;Tejero, Joanne D.;Prokop, Emily;Strutt, Tara M.;Sell, Stewart;Swain, Susan L.;McKinstry, Karl Kai
通讯作者：
McKinstry, Karl Kai