The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors.
The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors.
复制标题
DOI：
10.3390/ijms19030879
复制
发表时间：
2018-03-16
影响因子：
5.6
通讯作者：
Zakrzewska M
中科院分区：
文献类型：
--
作者：
Gruszka R;Zakrzewska M
核糖核酸的基本功能是在翻译过程中将遗传信息从DNA转移到蛋白质，然而，这并不是连接活性RNA序列与基本生物过程的唯一方式。迄今为止，许多不同大小、结构和生物学功能的RNA亚类已被鉴定。其中，有非编码单链microRNA（miRNA）。该亚类由长度为 19-25 个核苷酸的 RNA 组成，可调节明确的编码 RNA 的活性，并在许多生理和病理过程中发挥关键作用。 miRNA 基因位于外显子、内含子以及非翻译区域。从相邻的 miRNA 基因转录而来的几个 miRNA 称为簇。最大的簇之一是 miR-17-92 簇，由于其与肿瘤发生密切相关，因此被称为 OncomiR-1。 OncomiR-1 的 6 种 miRNA 已被证明在各种生理细胞过程中发挥重要作用，而且还通过抑制许多癌症相关过程中的细胞死亡发挥重要作用。由于序列的起源和相似性，定义了 miR-17-92 簇和旁系同源物、miR-106b-25 和 miR-106a-363 簇。在这里，我们讨论了在多种癌症（包括脑肿瘤）中发现的 miRNA 亚群的致癌功能。
The fundamental function of ribonucleic acids is to transfer genetic information from DNA to protein during translation process, however, this is not the only way connecting active RNA sequences with essential biological processes. Up until now, many RNA subclasses of different size, structure, and biological function were identified. Among them, there are non-coding single-stranded microRNAs (miRNAs). This subclass comprises RNAs of 19–25 nucleotides in length that modulate the activity of well-defined coding RNAs and play a crucial role in many physiological and pathological processes. miRNA genes are located both in exons, introns, and also within non-translated regions. Several miRNAs that are transcribed from the adjacent miRNA genes are called cluster. One of the largest ones is miR-17-92 cluster known as OncomiR-1 due to its strong link to oncogenesis. Six miRNAs from the OncomiR-1 have been shown to play important roles in various physiological cellular processes but also through inhibition of cell death in many cancer-relevant processes. Due to the origin and similarity of the sequence, miR-17-92 cluster and paralogs, miR-106b-25 and miR-106a-363 clusters were defined. Here we discuss the oncogenic function of those miRNA subgroups found in many types of cancers, including brain tumors.
登录
查看更多内容
影响因子：
11
作者：
Esposito MR;Aveic S;Seydel A;Tonini GP
通讯作者：
Tonini GP
DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
8
作者：
Ernst, A.;Campos, B.;Radlwimmer, B.
通讯作者：
Radlwimmer, B.
Mirbase：MicroRNA基因组学的工具。
影响因子：
14.9
作者：
Griffiths-Jones, Sam;Saini, Harpreet Kaur;van Dongen, Stijn;Enright, Anton J.
通讯作者：
Enright, Anton J.
影响因子：
14.9
作者：
Griffiths-Jones S;Grocock RJ;van Dongen S;Bateman A;Enright AJ
通讯作者：
Enright AJ