What the X has to do with it: differences in regulatory variability between the sexes in Drosophila simulans.
What the X has to do with it: differences in regulatory variability between the sexes in Drosophila simulans.
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X与之有什么关系：果蝇Simulans性别之间的调节变异性差异。
DOI：
10.1093/gbe/evu060
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发表时间：
2014-04
影响因子：
3.3
通讯作者：
Wayne ML
中科院分区：
文献类型：
--
作者：
Graze RM;McIntyre LM;Morse AM;Boyd BM;Nuzhdin SV;Wayne ML
The mechanistic basis of regulatory variation and the prevailing evolutionary forces shaping that variation are known to differ between sexes and between chromosomes. Regulatory variation of gene expression can be due to functional changes within a gene itself (cis) or in other genes elsewhere in the genome (trans). The evolutionary properties of cis mutations are expected to differ from mutations affecting gene expression in trans. We analyze allele-specific expression across a set of X substitution lines in intact adult Drosophila simulans to evaluate whether regulatory variation differs for cis and trans, for males and females, and for X-linked and autosomal genes. Regulatory variation is common (56% of genes), and patterns of variation within D. simulans are consistent with previous observations in Drosophila that there is more cis than trans variation within species (47% vs. 25%, respectively). The relationship between sex-bias and sex-limited variation is remarkably consistent across sexes. However, there are differences between cis and trans effects: cis variants show evidence of purifying selection in the sex toward which expression is biased, while trans variants do not. For female-biased genes, the X is depleted for trans variation in a manner consistent with a female-dominated selection regime on the X. Surprisingly, there is no evidence for depletion of trans variation for male-biased genes on X. This is evidence for regulatory feminization of the X, trans-acting factors controlling male-biased genes are more likely to be found on the autosomes than those controlling female-biased genes.
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影响因子：
3.3
作者：
Connallon T;Clark AG
通讯作者：
Clark AG
DOI：
10.1073/pnas.0805160105
发表时间：
2008-09-23
影响因子：
11.1
作者：
Lemos, Bernardo;Araripe, Luciana O.;Hartl, Daniel L.
通讯作者：
Hartl, Daniel L.
影响因子：
10.7
作者：
Graze, R. M.;Novelo, L. L.;McIntyre, L. M.
通讯作者：
McIntyre, L. M.
影响因子：
7
作者：
Emerson, J. J.;Hsieh, Li-Ching;Li, Wen-Hsiung
通讯作者：
Li, Wen-Hsiung
种群基因组学：果蝇果蝇中多态性和差异的全基因组分析。
影响因子：
9.8
作者：
Begun, David J.;Holloway, Alisha K.;Stevens, Kristian;Hillier, LaDeana W.;Poh, Yu-Ping;Hahn, Matthew W.;Nista, Phillip M.;Jones, Corbin D.;Kern, Andrew D.;Dewey, Colin N.;Pachter, Lior;Myers, Eugene;Langley, Charles H.
通讯作者：
Langley, Charles H.