Association between sex-biased gene expression and mutations with sex-specific phenotypic consequences in Drosophila.
Association between sex-biased gene expression and mutations with sex-specific phenotypic consequences in Drosophila.
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DOI：
10.1093/gbe/evr004
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发表时间：
2011
影响因子：
3.3
通讯作者：
Clark AG
中科院分区：
文献类型：
--
作者：
Connallon T;Clark AG
全基因组mRNA转录谱揭示了广泛的分子性二态性或“性别偏见”的基因表达，但分子和表型性二态性之间的关系仍然不清楚。一个主要的未解决的问题是，性别偏见的基因是否通常执行男性和女性特定的功能（这些基因是否具有性别偏见的表型或健身后果）或对两性具有相似的功能重要性。为了阐明性别偏见的转录和性别偏见的健身后果之间的关系，我们分析了一个大的数据集的致命的，可见的，不育的突变，已映射到果蝇基因组。这些数据使我们能够根据基因的性别特异性突变效应对基因进行分类，并推断性别偏向的转录水平和性别特异性适应性后果之间的关系。我们发现，在女性偏向的基因突变是（平均）更有害的女性比男性和男性偏向的基因突变往往是更有害的男性比女性。然而，大多数性别偏向基因的突变对两性具有相似的表型后果，这表明性别偏向转录不一定与男性和女性之间的功能遗传分化相关。这些结果对性二态性和性别特异性适应的进化有着有趣的意义。
Genome-wide mRNA transcription profiles reveal widespread molecular sexual dimorphism or “sex-biased” gene expression, yet the relationship between molecular and phenotypic sexual dimorphism remains unclear. A major unresolved question is whether sex-biased genes typically perform male- and female-specific functions (whether these genes have sex-biased phenotypic or fitness consequences) or have similar functional importance for both sexes. To elucidate the relationship between sex-biased transcription and sex-biased fitness consequences, we analyzed a large data set of lethal, visible, and sterile mutations that have been mapped to the Drosophila melanogaster genome. The data permitted us to classify genes according to their sex-specific mutational effects and to infer the relationship between sex-biased transcription level and sex-specific fitness consequences. We find that mutations in female-biased genes are (on average) more deleterious to females than to males and that mutations in male-biased genes tend to be more deleterious to males than to females. Nevertheless, mutations in most sex-biased genes have similar phenotypic consequences for both sexes, which suggests that sex-biased transcription is not necessarily associated with functional genetic differentiation between males and females. These results have interesting implications for the evolution of sexual dimorphism and sex-specific adaptation.
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影响因子：
64.8
作者：
Clark, Andrew G.;Eisen, Michael B.;MacCallum, Iain
通讯作者：
MacCallum, Iain
影响因子：
12.3
作者：
Parisi M;Nuttall R;Edwards P;Minor J;Naiman D;Lü J;Doctolero M;Vainer M;Chan C;Malley J;Eastman S;Oliver B
通讯作者：
Oliver B
影响因子：
12.3
作者：
McIntyre LM;Bono LM;Genissel A;Westerman R;Junk D;Telonis-Scott M;Harshman L;Wayne ML;Kopp A;Nuzhdin SV
通讯作者：
Nuzhdin SV
影响因子：
10.9
作者：
Arnold, Arthur P.;van Nas, Atila;Lusis, Aldons J.
通讯作者：
Lusis, Aldons J.
影响因子：
2.9
作者：
Mank, Judith E.;Hultin-Rosenberg, Lina;Ellegren, Hans
通讯作者：
Ellegren, Hans