Biocompatible Anisole-Nonlinear PEG Core-Shell Nanogels for High Loading Capacity, Excellent Stability, and Controlled Release of Curcumin.
Biocompatible Anisole-Nonlinear PEG Core-Shell Nanogels for High Loading Capacity, Excellent Stability, and Controlled Release of Curcumin.
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DOI：
10.3390/gels9090762
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发表时间：
2023-09-18
期刊：
影响因子：
4.6
通讯作者：
Zhou, Shuiqin
中科院分区：
文献类型：
--
作者：
Shen, Jing;Zhang, Jiangtao;Wu, Weitai;Banerjee, Probal;Zhou, Shuiqin
关键词：
姜黄素是一种无毒、价廉的天然药物，对糖尿病、癌症等多种疾病有很好的治疗效果。不幸的是，其极低的水溶性和在体内的快速降解严重限制了其生物利用度。本工作制备了一系列具有不同PEG凝胶壳厚度的生物相容性聚乙烯基苯甲醚@非线性聚乙二醇（PVAS@PEG）核壳纳米凝胶，以提供高水溶性、良好稳定性和可控缓释姜黄素。PVAS纳米凝胶核心旨在吸引和储存姜黄素分子，以获得高载药量，亲水性非线性PEG凝胶外壳旨在提供水溶性和热响应性药物释放。所制备的纳米凝胶呈单分散的球形，具有清晰的核壳结构。纳米凝胶的尺寸和壳层厚度可以通过改变核-壳前驱体的进料比来容易地控制。优化的PVAS@PEG纳米凝胶显示出38.0 wt%的高姜黄素负载量。纳米凝胶可以稳定姜黄素在pH = 7.4时的降解，并在生理温度范围内响应于热而释放姜黄素。纳米凝胶可以有效地进入细胞，并且在高达2.3mg/mL的浓度下对B16 F10和HL-7702细胞表现出可忽略的细胞毒性。这种设计的PVAS@PEG纳米凝胶具有用于有效药物递送的巨大潜力。
Curcumin, a nontoxic and cheap natural medicine, has high therapeutic efficacy for many diseases, including diabetes and cancers. Unfortunately, its exceedingly low water-solubility and rapid degradation in the body severely limit its bioavailability. In this work, we prepare a series of biocompatible poly(vinyl anisole)@nonlinear poly(ethylene glycol) (PVAS@PEG) core–shell nanogels with different PEG gel shell thickness to provide high water solubility, good stability, and controllable sustained release of curcumin. The PVAS nanogel core is designed to attract and store curcumin molecules for high drug loading capacity and the hydrophilic nonlinear PEG gel shell is designed to offer water dispersibility and thermo-responsive drug release. The nanogels prepared are monodispersed in a spherical shape with clear core–shell morphology. The size and shell thickness of the nanogels can be easily controlled by changing the core–shell precursor feeding ratios. The optimized PVAS@PEG nanogels display a high curcumin loading capacity of 38.0 wt%. The nanogels can stabilize curcumin from degradation at pH = 7.4 and release it in response to heat within the physiological temperature range. The nanogels can enter cells effectively and exhibit negligible cytotoxicity to both the B16F10 and HL-7702 cells at a concentration up to 2.3 mg/mL. Such designed PVAS@PEG nanogels have great potential to be used for efficient drug delivery.
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影响因子：
5.5
作者：
Howaili F;Özliseli E;Küçüktürkmen B;Razavi SM;Sadeghizadeh M;Rosenholm JM
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