Alteration of cell cycle progression by Sindbis virus infection.

Alteration of cell cycle progression by Sindbis virus infection.
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辛德比斯病毒感染改变细胞周期进程。

DOI:
10.1016/j.bbrc.2015.04.148
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发表时间:
2015
期刊:
Biochem Biophys Res Commun.
影响因子:
--
通讯作者:
Shirasawa H.
Shirasawa H.
中科院分区:
--
文献类型:
--
作者:
Yi R;Saito K;Isegawa N;Shirasawa H.

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We examined the impact of Sindbis virus (SINV) infection on cell cycle progression in a cancer cell line, HeLa, and a non-cancerous cell line, Vero. Cell cycle analyses showed that SINV infection is able to alter the cell cycle progression in both HeLa and Vero cells, but differently, especially during the early stage of infection. SINV infection affected the expression of several cell cycle regulators (CDK4, CDK6, cyclin E, p21, cyclin A and cyclin B) in HeLa cells and caused HeLa cells to accumulate in S phase during the early stage of infection. Monitoring SINV replication in HeLa and Vero cells expressing cell cycle indicators revealed that SINV which infected HeLa cells during G1phase preferred to proliferate during S/G2phase, and the average time interval for viral replication was significantly shorter in both HeLa and Vero cells infected during G1phase than in cells infected during S/G2phase.
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