Membrane Simulation Models from Nanometer to Micrometer Scale

Membrane Simulation Models from Nanometer to Micrometer Scale
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从纳米到微米尺度的膜模拟模型

DOI:
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发表时间:
2008
期刊:
影响因子:
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通讯作者:
H. Noguchi
H. Noguchi
中科院分区:
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文献类型:
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作者:
H. Noguchi

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综述了近年来脂膜模拟模型的研究进展。为了降低计算成本,已经提出了各种粗粒度的分子模型。其中,隐式溶剂(无溶剂)分子模型是相对更粗粒度和有效的模拟大双层膜。在微米尺度上,分子的细节通常可以忽略不计,膜可以被描述为一个连续的曲面。提出了流体和弹性膜的网格或无网格离散理论模型。作为应用的例子,在流动,囊泡形成和膜融合的囊泡的动力学。
Recent developments in lipid membrane models for simulations are reviewed. To reduce computational costs, various coarse-grained molecular models have been proposed. Among them, implicit solvent (solvent-free) molecular models are relatively more coarse-grained and efficient for simulating large bilayer membranes. On a µm scale, the molecular details are typically negligible and the membrane can be described as a continuous curved surface. The theoretical models for fluid and elastic membranes with mesh or meshless discretizations are presented. As examples of applications, the dynamics of vesicles in flows, vesicle formation, and membrane fusion are presented.
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