Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening.
Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening.
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DOI：
10.3389/fphar.2021.779753
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发表时间：
2021
影响因子：
5.6
通讯作者：
Ju LA
中科院分区：
文献类型：
--
作者：
Zhang Y;Jiang F;Chen Y;Ju LA
血小板功能测试对于分析止血和血栓形成中的血小板功能障碍和失调至关重要。在临床上，它们为患者管理和治疗评估提供重要指导。近年来，血流动力学和收缩力对血小板功能引起的生物力学效应引起了越来越多的关注。不幸的是，市场上现有的血小板功能测试并未充分结合局部血小板力学生物学的作用。此外，它们通常是昂贵且笨重的系统，需要大量样本和较长的处理时间。为此，出现了许多新颖的微流体技术来模拟血管解剖结构、整合血流动力学参数并概括血小板力学生物学。这些小型化且经济高效的微流体装置为高通量、快速和可扩展的血小板功能测试、血液疾病分析和抗血小板药物筛选提供了线索。此外，现有的抗血小板药物常常疗效不佳，同时对某些个体会产生一些不良的出血副作用。在一些成功商业化并应用于临床实践的微流控系统的推动下，结合血小板力学生物学的微流控技术具有作为方便、高效且廉价的患者监测和治疗评估的即时护理工具的巨大潜力。在此，我们首先总结一下常规的和市售的血小板功能测试。然后我们重点介绍受血小板力学生物学启发的微流体技术的最新进展。最后但并非最不重要的一点是，我们讨论了微流体作为血小板功能测试和抗血小板药物筛选的即时护理工具的未来潜力。
Platelet function tests are essential to profile platelet dysfunction and dysregulation in hemostasis and thrombosis. Clinically they provide critical guidance to the patient management and therapeutic evaluation. Recently, the biomechanical effects induced by hemodynamic and contractile forces on platelet functions attracted increasing attention. Unfortunately, the existing platelet function tests on the market do not sufficiently incorporate the topical platelet mechanobiology at play. Besides, they are often expensive and bulky systems that require large sample volumes and long processing time. To this end, numerous novel microfluidic technologies emerge to mimic vascular anatomies, incorporate hemodynamic parameters and recapitulate platelet mechanobiology. These miniaturized and cost-efficient microfluidic devices shed light on high-throughput, rapid and scalable platelet function testing, hematological disorder profiling and antiplatelet drug screening. Moreover, the existing antiplatelet drugs often have suboptimal efficacy while incurring several adverse bleeding side effects on certain individuals. Encouraged by a few microfluidic systems that are successfully commercialized and applied to clinical practices, the microfluidics that incorporate platelet mechanobiology hold great potential as handy, efficient, and inexpensive point-of-care tools for patient monitoring and therapeutic evaluation. Hereby, we first summarize the conventional and commercially available platelet function tests. Then we highlight the recent advances of platelet mechanobiology inspired microfluidic technologies. Last but not least, we discuss their future potential of microfluidics as point-of-care tools for platelet function test and antiplatelet drug screening.
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三维微流体装置，用于监测癌症和化学疗法相关的血小板激活。
影响因子：
4.1
作者：
Hao Z;Lv H;Tan R;Yang X;Liu Y;Xia YL
通讯作者：
Xia YL
影响因子：
9.8
作者：
Bolliger, D.;Dell-Kuster, S.;Filipovic, M.
通讯作者：
Filipovic, M.
影响因子：
3.8
作者：
Conant, Carolyn G.;Schwartz, Michael A.;Nevill, J. Tanner
通讯作者：
Nevill, J. Tanner
影响因子：
37.8
作者：
Dlott, Jeffrey S.;George, Roberta A.;Hylek, Elaine M.
通讯作者：
Hylek, Elaine M.
通过基质传感进行血小板产生的新路径。
影响因子：
10.1
作者：
Abbonante V;Di Buduo CA;Gruppi C;De Maria C;Spedden E;De Acutis A;Staii C;Raspanti M;Vozzi G;Kaplan DL;Moccia F;Ravid K;Balduini A
通讯作者：
Balduini A