Body mass index and the risk of dementia among Louisiana low income diabetic patients.
Body mass index and the risk of dementia among Louisiana low income diabetic patients.
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DOI：
10.1371/journal.pone.0044537
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Katzmarzyk PT
中科院分区：
文献类型：
--
作者：
Hu G;Horswell R;Wang Y;Li W;Besse J;Xiao K;Chen H;Keller JN;Heymsfield SB;Ryan DH;Katzmarzyk PT
肥胖和痴呆风险之间的关联仍然存在争议，没有研究评估糖尿病患者之间的这种关联。本研究的目的是调查中、低收入糖尿病患者的体重指数（BMI）与痴呆风险之间的关系。样本包括路易斯安那州立大学基于医院的纵向研究中的44，660名糖尿病患者（19，618名白色和25，042名非洲裔美国人），年龄在30至96岁之间，没有痴呆病史。在平均3.9年的随访期间，388名受试者发生了痴呆症。不同BMI水平下痴呆事件的年龄和性别调整风险比（HR）（≤25、25-26.9、27-29.9、30-34.9和≥35 kg/m2）分别为1.00、0.53（95% CI 0.34-0.83），0.29（0.18-0.45）、0.37（0.25-0.56）和0.31（0.21-0.48）（P趋势<0.001），在白色糖尿病患者中为1.00，1.00（95% CI 0.62-1.63），0.62（0.39-0.98），0.56（0.36-0.86）和0.65（0.43-1.01）（P趋势 = 0.029）。对其他混杂因素的进一步调整仅对结果产生轻微影响。种族和BMI对痴呆风险有显著的交互作用（χ2 = 5.52，1df，p<0.025），白色患者中这种关联更强。 在分层分析中，BMI与痴呆风险之间的多变量校正负相关存在于年龄55-64岁、65-74岁和≥75岁的受试者、男性和女性、非吸烟者和吸烟者以及具有不同类型健康保险的受试者中。在糖尿病患者中，较高的基线BMI与较低的痴呆风险相关，并且这种关联在白色糖尿病患者中比在非裔美国人糖尿病患者中更强。
The association between obesity and dementia risk remains debatable and no studies have assessed this association among diabetic patients. The aim of our study was to investigate the association between body mass index (BMI) and dementia risk among middle and low income diabetic patients. The sample included 44,660 diabetic patients (19,618 white and 25,042 African American) 30 to 96 years of age without a history of dementia in the Louisiana State University Hospital-Based Longitudinal Study. During a mean follow-up period of 3.9 years, 388 subjects developed incident dementia. The age- and sex-adjusted hazards ratios (HRs) for incident dementia at different levels of BMI (≤25, 25–26.9, 27–29.9, 30–34.9, and ≥35 kg/m2) were 1.00, 0.53 (95% CI 0.34–0.83), 0.29 (0.18–0.45), 0.37 (0.25–0.56), and 0.31 (0.21–0.48) (Ptrend<0.001) in white diabetic patients, and 1.00, 1.00 (95% CI 0.62–1.63), 0.62 (0.39–0.98), 0.56 (0.36–0.86), and 0.65 (0.43–1.01) (Ptrend = 0.029) in African American diabetic patients. Further adjustment for other confounding factors affected the results only slightly. There was a significant interaction between race and BMI on dementia risk (χ2 = 5.52, 1df, p<0.025), such that the association was stronger in white patients. In stratified analyses, the multivariate-adjusted inverse association between BMI and risk of dementia was present in subjects aged 55–64 years, 65–74 years, and ≥75 years, in men and women, in non-smokers and smokers, and in subjects with different types of health insurance. Higher baseline BMI was associated with a lower risk of dementia among diabetic patients, and this association was stronger among white than among African American diabetic patients.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
14
作者：
通讯作者：
--
与中年和老年人的心血管危险因素有关的痴呆症住院风险：社区中的动脉粥样硬化风险（ARIC）研究。
影响因子：
11
作者：
Alonso, A.;Mosley, T. H., Jr.;Gottesman, R. F.;Catellier, D.;Sharrett, A. R.;Coresh, J.
通讯作者：
Coresh, J.
影响因子：
16.2
作者：
Cowie CC;Rust KF;Ford ES;Eberhardt MS;Byrd-Holt DD;Li C;Williams DE;Gregg EW;Bainbridge KE;Saydah SH;Geiss LS
通讯作者：
Geiss LS
影响因子：
16.2
作者：
Hu G;Bouchard C;Bray GA;Greenway FL;Johnson WD;Newton RL Jr;Ravussin E;Ryan DH;Katzmarzyk PT
通讯作者：
Katzmarzyk PT