Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006.
Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006.
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DOI：
10.2337/dc08-1296
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发表时间：
2009-02
期刊：
影响因子：
16.2
通讯作者：
Geiss LS
中科院分区：
文献类型：
--
作者：
Cowie CC;Rust KF;Ford ES;Eberhardt MS;Byrd-Holt DD;Li C;Williams DE;Gregg EW;Bainbridge KE;Saydah SH;Geiss LS
目的：我们在2005-2006年间通过空腹和2小时口服葡萄糖耐量试验检测了美国已确诊糖尿病、未确诊糖尿病和糖尿病前期的患病率。然后，我们将这些疾病的流行情况与1988-1994年的情况进行了比较。研究设计和方法--2005年至2006年，国家健康和营养检查调查纳入了7,267名12岁≥人群的概率样本。参与者通过对诊断为糖尿病的访谈以及在子样本中测量的空腹和2-h葡萄糖值来对血糖状况进行分类。结果：2005年至2006年，≥20岁人群的总糖尿病粗患病率为12.9%，其中40%的∼未确诊。在年龄为20岁的≥人群中，空腹血糖受损的粗略患病率为25.7%，糖耐量受损的粗略患病率为13.8%，几乎30%的人两者都有。超过40%的人患有糖尿病或糖尿病前期。近三分之一的老年人患有糖尿病，四分之三的人患有糖尿病或糖尿病前期。与非西班牙裔白人相比，在非西班牙裔黑人(P<；0.0001)和墨西哥裔美国人(P=0.0001)中，确诊糖尿病的年龄和性别标准化患病率大约是后者的两倍，而未确诊糖尿病的患病率并不更高。年龄在20岁的≥人群中确诊糖尿病的粗患病率从1988年至1994年的5.1%上升到2005年至2006年的7.7%(P=0.0001)；考虑到年龄和性别的差异，特别是在非西班牙裔黑人中，这一比例显著上升。未确诊的糖尿病和前期糖尿病的患病率总体上是稳定的，尽管在墨西哥裔美国人中未确诊的糖尿病总比例有所下降。结论：在20岁的≥人群中，超过40%的人患有高血糖，少数人群的患病率更高。随着时间的推移，确诊的糖尿病患者有所增加，但其他情况相对稳定。
OBJECTIVE—We examined the prevalences of diagnosed diabetes, and undiagnosed diabetes and pre-diabetes using fasting and 2-h oral glucose tolerance test values, in the U.S. during 2005–2006. We then compared the prevalences of these conditions with those in 1988–1994. RESEARCH DESIGN AND METHODS—In 2005–2006, the National Health and Nutrition Examination Survey included a probability sample of 7,267 people aged ≥12 years. Participants were classified according to glycemic status by interview for diagnosed diabetes and by fasting and 2-h glucoses measured in subsamples. RESULTS—In 2005–2006, the crude prevalence of total diabetes in people aged ≥20 years was 12.9%, of which ∼40% was undiagnosed. In people aged ≥20 years, the crude prevalence of impaired fasting glucose was 25.7% and of impaired glucose tolerance was 13.8%, with almost 30% having either. Over 40% of individuals had diabetes or pre-diabetes. Almost one-third of the elderly had diabetes, and three-quarters had diabetes or pre-diabetes. Compared with non-Hispanic whites, age- and sex-standardized prevalence of diagnosed diabetes was approximately twice as high in non-Hispanic blacks (P < 0.0001) and Mexican Americans (P = 0.0001), whereas undiagnosed diabetes was not higher. Crude prevalence of diagnosed diabetes in people aged ≥20 years rose from 5.1% in 1988–1994 to 7.7% in 2005–2006 (P = 0.0001); this was significant after accounting for differences in age and sex, particularly in non-Hispanic blacks. Prevalences of undiagnosed diabetes and pre-diabetes were generally stable, although the proportion of total diabetes that was undiagnosed decreased in Mexican Americans. CONCLUSIONS—Over 40% of people aged ≥20 years have hyperglycemic conditions, and prevalence is higher in minorities. Diagnosed diabetes has increased over time, but other conditions have been relatively stable.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
16.2
作者：
Gregg, EW;Cadwell, BL;Vinicor, F
通讯作者：
Vinicor, F
影响因子：
16.2
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通讯作者：
--
影响因子：
16.2
作者：
Cowie, Catherine C.;Engelgau, Michael M.;Gregg, Edward W.
通讯作者：
Gregg, Edward W.