Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment.
Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment.
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DOI：
10.1002/advs.202203291
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发表时间：
2022-10
期刊：
影响因子：
15.1
通讯作者：
Xie, Jingwei
中科院分区：
文献类型：
--
作者：
Su, Yajuan;Yrastorza, Jaime T.;Matis, Mitchell;Cusick, Jenna;Zhao, Siwei;Wang, Guangshun;Xie, Jingwei
由于生物膜相关感染的持续上升，生物膜严重威胁人类健康。生物膜的形成使传统抗生素失效并抑制免疫清除。因此，了解生物膜形成的机制并开发新的策略来更有效地处理生物膜非常重要。这篇综述文章首先介绍了各种临床情况下的生物膜形成及其相应的治疗方法。然后总结了研究中使用的已建立的生物膜模型。进一步讨论了可能有助于制定对抗生物膜新策略的潜在目标。随后介绍了最近开发的用于预防和治疗生物膜的新技术，包括抗菌表面涂层、生物膜的物理去除、新抗菌分子的开发以及抗菌剂的输送。最后指出了今后的研究方向。本综述首先描述了各种临床情况下生物膜的形成及其临床管理。然后，讨论了研究中使用的已建立的生物膜模型和生物膜的潜在目标。最后，本综述重点介绍了预防和治疗生物膜的新兴新技术。
Due to the continuous rise in biofilm‐related infections, biofilms seriously threaten human health. The formation of biofilms makes conventional antibiotics ineffective and dampens immune clearance. Therefore, it is important to understand the mechanisms of biofilm formation and develop novel strategies to treat biofilms more effectively. This review article begins with an introduction to biofilm formation in various clinical scenarios and their corresponding therapy. Established biofilm models used in research are then summarized. The potential targets which may assist in the development of new strategies for combating biofilms are further discussed. The novel technologies developed recently for the prevention and treatment of biofilms including antimicrobial surface coatings, physical removal of biofilms, development of new antimicrobial molecules, and delivery of antimicrobial agents are subsequently presented. Finally, directions for future studies are pointed out. This review first describes the formation of biofilms in various clinical scenarios and their clinical management. Then, the established biofilms models used in research and the potential targets for biofilms are discussed. Finally, this review highlights the emerging novel technologies for the prevention and treatment of biofilms.
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