Heart Failure in Chronic Infectious and Inflammatory Conditions: Mechanistic Insights from Clinical Heterogeneity.
Heart Failure in Chronic Infectious and Inflammatory Conditions: Mechanistic Insights from Clinical Heterogeneity.
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慢性感染性和炎症性心力衰竭：来自临床异质性的机制见解。
DOI：
10.1007/s11897-022-00560-3
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发表时间：
2022-10
影响因子：
--
通讯作者：
Feinstein, Matthew J.
中科院分区：
文献类型：
--
作者：
Beydoun, Nour;Feinstein, Matthew J.
关键词：
炎症及其分解之间的平衡在心力衰竭(HF)的发病机制中发挥着重要且日益受到重视的作用。在人类中，不同的慢性炎症条件和对感染的免疫炎症反应可导致不同的HF表现。回顾这些HF的表型和机制的多样性提供了有用的临床和科学见解。慢性炎症性和自身免疫性疾病患者发生心力衰竭的风险增加，且与疾病严重程度有关。存在炎症条件下特定的心衰表现，潜在的病理生理原因可能因条件不同而不同。尽管炎症性疾病对心力衰竭的具体表现有所不同，但慢性过度的炎症和与炎症消退相关的自身炎症是心力衰竭的共同潜在因素。需要进一步的研究来提炼炎症状态特定的心衰病理生理和预后的表型，以及潜在的干预靶点。
The balance between inflammation and its resolution plays an important and increasingly appreciated role in heart failure (HF) pathogenesis. In humans, different chronic inflammatory conditions and immune-inflammatory responses to infection can lead to diverse HF manifestations. Reviewing the phenotypic and mechanistic diversity of these HF presentations offers useful clinical and scientific insights. HF risk is increased in patients with chronic inflammatory and autoimmune disorders and relates to disease severity. Inflammatory condition–specific HF manifestations exist and underlying pathophysiologic causes may differ across conditions. Although inflammatory disease–specific presentations of HF differ, chronic excess in inflammation and auto-inflammation relative to resolution of this inflammation is a common underlying contributor to HF. Further studies are needed to phenotypically refine inflammatory condition–specific HF pathophysiologies and prognoses, as well as potential targets for intervention.
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DOI：
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发表时间：
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期刊：
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