Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3.
Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3.
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牙周病和炎症性关节炎之间的关联揭示了 3 型黑皮质素受体的调节功能。
DOI：
10.1016/j.ajpath.2014.04.009
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Montero-Melendez T
中科院分区：
文献类型：
--
作者：
Montero-Melendez T
由于有临床证据表明牙周病和类风湿关节炎之间存在关联，因此开发合适的实验模型以探索致病机制和治疗机会非常重要。使用不同的方案应用炎性关节炎的K/BxN血清模型，并且与黑皮质素（MC）受体激动剂DTrp 8-γ-黑素细胞刺激激素（MSH; DTrp）相比，建立了地塞米松和降钙素提供的关节破坏的调节。还使用了不同年龄的野生型和MC受体3型（MC 3）-无效小鼠。关节疾病的严重程度之间有显着的关联，诱导不同的协议和体积的致关节炎的K/BxN血清，牙周骨损伤。每只小鼠用10 μg地塞米松、30 ng依降钙素和20 μg DTrp进行治疗性处理显示出独特和独特的药理学性质，其中仅DTrp保护关节和牙周组织。在非关节炎动物中的进一步分析显示，与野生型小鼠相比，Mc 3r −/−小鼠对牙周骨丢失的易感性更高，在14周龄时显著加重。这些数据揭示了内源性MC 3对健康和疾病中牙周状况的新保护特性，并表明MC 3活化可能导致开发一种新的抗关节炎骨保护疗法。
Because there is clinical evidence for an association between periodontal disease and rheumatoid arthritis, it is important to develop suitable experimental models to explore pathogenic mechanisms and therapeutic opportunities. The K/BxN serum model of inflammatory arthritis was applied using distinct protocols, and modulation of joint disruption afforded by dexamethasone and calcitonin was established in comparison to the melanocortin (MC) receptor agonist DTrp8–γ-melanocyte stimulating hormone (MSH; DTrp). Wild-type and MC receptor type 3 (MC3)-null mice of different ages were also used. There was significant association between severity of joint disease, induced with distinct protocols and volumes of the arthritogenic K/BxN serum, and periodontal bone damage. Therapeutic treatment with 10 μg dexamethasone, 30 ng elcatonin, and 20 μg DTrp per mouse revealed unique and distinctive pharmacological properties, with only DTrp protecting both joint and periodontal tissue. Further analyses in nonarthritic animals revealed higher susceptibility to periodontal bone loss inMc3r−/−compared with wild-type mice, with significant exacerbation at 14 weeks of age. These data reveal novel protective properties of endogenous MC3on periodontal status in health and disease and indicate that MC3activation could lead to the development of a new genus of anti-arthritic bone-sparing therapeutics.
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影响因子：
3.5
作者：
Liang S;Hosur KB;Domon H;Hajishengallis G
通讯作者：
Hajishengallis G
影响因子：
3.7
作者：
Al-Kashi A;Montero-Melendez T;Moradi-Bidhendi N;Gilligan JP;Mehta N;Perretti M
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影响因子：
3.9
作者：
J. Ritter;Kerr Ld;J. Valeriano‐Marcet;H. Spiera
通讯作者：
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影响因子：
--
作者：
Scher, Jose U.;Ubeda, Carles;Equinda, Michele;Khanin, Raya;Buischi, Yvonne;Viale, Agnes;Lipuma, Lauren;Attur, Mukundan;Pillinger, Michael H.;Weissmann, Gerald;Littman, Dan R.;Pamer, Eric G.;Bretz, Walter A.;Abramson, Steven B.
通讯作者：
Abramson, Steven B.
影响因子：
4.8
作者：
Patel, Hetal B.;Bombardieri, Michele;Perretti, Mauro
通讯作者：
Perretti, Mauro