Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis.
Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis.
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DOI：
10.1002/art.34539
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发表时间：
2012-10
影响因子：
--
通讯作者：
Abramson, Steven B.
中科院分区：
文献类型：
--
作者：
Scher, Jose U.;Ubeda, Carles;Equinda, Michele;Khanin, Raya;Buischi, Yvonne;Viale, Agnes;Lipuma, Lauren;Attur, Mukundan;Pillinger, Michael H.;Weissmann, Gerald;Littman, Dan R.;Pamer, Eric G.;Bretz, Walter A.;Abramson, Steven B.
分析从未治疗过的新发类风湿性关节炎（诺拉）患者的龈下口腔微生物群丰度和多样性。在诺拉、慢性RA（CRA）患者和健康受试者中确定了牙周病（PD）状态、临床活动和社会人口学因素。使用大规模平行焦磷酸测序来比较龈下微生物群的组成，并建立细菌的存在/丰度与疾病表型之间的相关性。检测抗牙龈卟啉单胞菌抗体以评估既往暴露。在诺拉患者中，更晚期的牙周炎在疾病发作时就已经存在。诺拉的龈下微生物群与对照组不同。然而，在大多数情况下，这些差异可归因于PD的严重程度，而不是RA所固有的。牙龈卟啉单胞菌的存在和丰度也与PD严重程度直接相关，并非RA所特有，并且与抗瓜氨酸肽抗体（ACPA）滴度无关。在RA和对照组中，牙龈卟啉单胞菌的总体暴露量相似，分别为78.4%和83.3%。双生厌氧球菌与ACPA/RF的存在相关。普雷沃菌属和钩端毛菌属是诺拉组中唯一的特征性分类群，与PD状态无关。诺拉患者在疾病发作时表现出较高的PD患病率，尽管他们年龄较小且缺乏吸烟史。诺拉患者的龈下微生物群与CRA和PD严重程度相当的健康受试者相似。尽管牙龈卟啉单胞菌定植与PD严重程度相关，但各组的总体暴露量相似。A的作用。geminatus和Prevotella/Leptotrichia物种在该过程中的作用值得进一步研究。
To profile the subgingival oral microbiota abundance and diversity in never-treated, new-onset rheumatoid arthritis (NORA) patients. Periodontal disease (PD) status, clinical activity and sociodemographic factors were determined in patients with NORA, chronic RA (CRA) and healthy subjects. Massively parallel pyrosequencing was used to compare the composition of subgingival microbiota and establish correlations between presence/abundance of bacteria and disease phenotypes. Anti-P. gingivalis antibodies were tested to assess prior exposure. The more advanced forms of periodontitis are already present at disease onset in NORA patients. The subgingival microbiota of NORA is distinct from controls. In most cases, however, these differences can be attributed to PD severity and are not inherent to RA. The presence and abundance of P. gingivalis is directly associated with PD severity as well, is not unique to RA, and does not correlate with anti-citrullinated peptide antibody (ACPA) titers. Overall exposure to P. gingivalis is similar in RA and controls, observed in 78.4% and 83.3%, respectively. Anaeroglobus geminatus correlated with ACPA/RF presence. Prevotella and Leptotrichia species are the only characteristic taxa in the NORA group irrespective of PD status. NORA patients exhibit a high prevalence of PD at disease onset, despite their young age and paucity of smoking history. The subgingival microbiota of NORA patients is similar to CRA and healthy subjects of comparable PD severity. Although colonization with P. gingivalis correlates with PD severity, overall exposure is similar among groups. The role of A. geminatus and Prevotella/Leptotrichia species in this process merits further study.
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
9.4
作者：
Kumar, PS;Griffen, AL;Leys, EJ
通讯作者：
Leys, EJ
影响因子：
3.9
作者：
Hitchon, Carol A.;Chandad, Fatiha;El-Gabalawy, Hani S.
通讯作者：
El-Gabalawy, Hani S.
影响因子：
9.4
作者：
Delima, Suzanne L.;McBride, Robert K.;Kumar, Purnima S.
通讯作者：
Kumar, Purnima S.
影响因子：
5.1
作者：
Huse SM;Welch DM;Morrison HG;Sogin ML
通讯作者：
Sogin ML