A biomimetic nanosponge that absorbs pore-forming toxins.
A biomimetic nanosponge that absorbs pore-forming toxins.
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一种吸收孔形成毒素的仿生纳米质体。
DOI：
10.1038/nnano.2013.54
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发表时间：
2013-05
影响因子：
38.3
通讯作者：
中科院分区：
文献类型：
--
作者：
解毒治疗，如毒素靶向抗毒力治疗，提供了清除体内由细菌感染、有毒伤害和生物武器引起的毒力因子的方法。由于现有的解毒平台，如抗血清，单克隆抗体，小分子抑制剂和分子印迹聚合物通过靶向毒素的分子结构起作用，因此需要针对不同疾病进行定制治疗。在这里，我们展示了一种仿生毒素纳米海绵，其在体内起着毒素诱饵的作用。纳米海绵由一个被红细胞膜包围的聚合物纳米颗粒核心组成，它吸收破坏膜的毒素，并将它们从细胞靶点转移出去。在小鼠模型中，纳米海绵显著降低了葡萄球菌α-溶血素（α-毒素）的毒性，从而提高了毒素攻击小鼠的存活率。这种生物启发的毒素纳米海绵提供了一种解毒治疗，可以潜在地治疗由成孔毒素引起的各种损伤和疾病。
Detoxification treatments such as toxin-targeted anti-virulence therapy offer ways to cleanse the body of virulence factors that are caused by bacterial infections, venomous injuries, and biological weaponry. Because existing detoxification platforms such as antisera, monoclonal antibodies, small-molecule inhibitors, and molecularly imprinted polymers act by targeting the molecular structures of the toxins, customized treatments are required for different diseases. Here we show a biomimetic toxin nanosponge that functions as a toxin decoy in vivo. The nanosponge, which consists of a polymeric nanoparticle core surrounded by red blood cell membranes, absorbs membrane-damaging toxins and diverts them away from their cellular targets. In a mouse model, the nanosponges markedly reduce the toxicity of staphylococcal alpha-hemolysin (α-toxin) and thus improve the survival rate of toxin-challenged mice. This biologically inspired toxin nanosponge presents a detoxification treatment that can potentially treat a variety of injuries and diseases caused by pore-forming toxins.
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影响因子：
2.8
作者：
Beghini, DG;Hernandez-Oliveira, S;Marangoni, S
通讯作者：
Marangoni, S
影响因子：
38.3
作者：
Leroux, Jean-Christophe
通讯作者：
Leroux, Jean-Christophe
影响因子：
3.4
作者：
Rosado CJ;Kondos S;Bull TE;Kuiper MJ;Law RH;Buckle AM;Voskoboinik I;Bird PI;Trapani JA;Whisstock JC;Dunstone MA
通讯作者：
Dunstone MA
影响因子：
16.6
作者：
Gao, Weiwei;Langer, Robert;Farokhzad, Omid C.
通讯作者：
Farokhzad, Omid C.
影响因子：
3.1
作者：
OHANLEY, P;LALONDE, G;JI, G
通讯作者：
JI, G