Differential effects of AdOx on gene expression in P19 embryonal carcinoma cells.
Differential effects of AdOx on gene expression in P19 embryonal carcinoma cells.
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AdOx 对 P19 胚胎癌细胞基因表达的不同影响
DOI：
10.1186/1471-2202-13-6
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发表时间：
2012-01-06
期刊：
影响因子：
2.4
通讯作者：
Shen YF
中科院分区：
文献类型：
--
作者：
Yan L;Zhao HY;Zhang Y;Shen YF
BackgroundPluripotent cells maintain a unique gene expression pattern and specific chromatin signature. In this study, we explored the effect of the methyltransferase inhibitor adenosine dialdehyde (AdOx) on pluripotency maintenance and gene expression in P19 embryonal carcinoma cells.ResultsAfter AdOx treatment, the pluripotency-related gene network became disordered, and the early developmental genes were released from the repression. Remarkably, AdOx caused contrasting effects on the expression of two key pluripotency genes,nanogandoct3/4, with the reduction of the repressive histone marks H3K27me3, H3K9me3 and H3K9me2 only in thenanoggene.ConclusionsKey pluripotency genes were controlled by different mechanisms, including the differential enrichment of repressive histone methylation marks. These data provided novel clues regarding the critical role of histone methylation in the maintenance of pluripotency and the determination of cell fate in P19 pluripotent cells.
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影响因子：
64.5
作者：
Thomson M;Liu SJ;Zou LN;Smith Z;Meissner A;Ramanathan S
通讯作者：
Ramanathan S
影响因子：
2.7
作者：
Messerschmidt, Daniel M.;Kemler, Rolf
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Kemler, Rolf
影响因子：
5.3
作者：
EDWARDS, MKS;HARRIS, JF;MCBURNEY, MW
通讯作者：
MCBURNEY, MW
影响因子：
4.8
作者：
Li, Zhao-yong;Yang, Jun;Shen, Yu-fei
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Shen, Yu-fei
影响因子：
5.3
作者：
Chew, JL;Loh, YH;Ng, HH
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Ng, HH